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. 2019 Mar 28;9:5297. doi: 10.1038/s41598-019-41629-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Macrophage recruitment to the liver is modified by cell specific deficiency of TNFR1 after BCG infection. (a) Representative zebra plot showing liver cells in naïve littermates and at 2-weeks post-infection, liver myeloid subsets were identified by CD11b and Gr-1 expression from LMC obtained from WT, TNFR1 KO, TNFR1-M KO, and TNFR1-T KO mice. (b) Frequency of Neutrophils (CD11b⁺Gr-1^high), (c) Monocytes (CD11b⁺Gr-1^Interm) and (d) Macrophages (CD11b⁺Gr-1⁻) is shown. (e) Representative zebra plot showing liver cells in naïve littermates and at 2-weeks post-infection, liver myeloid subsets were identified as in (a) with LMC obtained from TNFR2-Flox, TNFR2-M KO and TNFR2-T KO. (f) Frequency of Neutrophils (CD11b⁺Gr-1^high), (g) Monocytes (CD11b⁺Gr-1^Interm) and (h) Macrophages (CD11b⁺Gr-1⁻) is shown. Results are representative of three independent experiments. Bar graphs shown mean +/− SEM, n = 3 to 9 mice per group (B and C). *p < 0.05, **p < 0.01, ***p < 0.001 versus WT, Multiple t test and Bonferroni-Dunn were used to multiple comparison.