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. 2019 Mar 28;9:5305. doi: 10.1038/s41598-019-41489-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PtNPs induce DNA cleavage in presence and absence of gyrase. Different reactions were setup: Relaxed pHOT-1 DNA (substrate) with (i) gyrase and Ciprofloxacin (positive control) (ii) gyrase and PtNPs (iii) gyrase (iv) PtNPs. The samples were loaded on 1% agarose gel with appropriate markers electrophoresed and imaged and a representative gel image is presented here. The full length gel image is shown as Supplementary Fig. 15). Red arrows indicate cleaved DNA generated due to PtNP treatment. Lane Description: L1 – Relaxed DNA + gyrase + Ciprofloxacin; L2 – Relaxed DNA + gyrase + PtNPs; L3- Relaxed DNA + gyrase; L4 – Relaxed DNA + PtNPs; L5 – Relaxed DNA.