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Proposed model for P2X7 and GSDM-D-mediated microparticulate IL-1β release. Microparticulate IL-1β release regulated by GSDM-D and P2X7 is a two-step process. GSDM-D activation regulating the release of IL-1β and P2X7 into microparticles, followed by microparticulate active P2X7 receptor regulating bioactive mature IL-1β release from the microparticles to target cells
