Table 2.
Characteristics of the subjects
| SNP | Genotypes (no.) | Age (years) | BMI (kg/m2) | Infertility duration (years) | AFC (n) | bFSH (IU/L) | bLH (IU/L) | AMH (ng/mL) | Total Gn dose (IU) |
|---|---|---|---|---|---|---|---|---|---|
| rs2853691 | AA (n = 590) | 32.31 ± 4.87 | 21.59 ± 2.97 | 4.75 ± 3.65 | 15.30 ± 9.58 | 8.44 ± 5.77 | 5.45 ± 4.04 | 4.79 ± 3.68 | 2118.75 ± 909.86 |
| AG (n = 327) | 32.74 ± 4.66 | 21.12 ± 3.06 | 4.75 ± 3.18 | 15.21 ± 9.43 | 8.29 ± 3.31 | 5.33 ± 3.35 | 5.19 ± 7.20 | 2107.91 ± 818.95 | |
| GG (n = 32) | 32.34 ± 4.76 | 21.13 ± 3.14 | 5.25 ± 3.82 | 16.67 ± 11.83 | 8.05 ± 3.40 | 5.72 ± 2.78 | 5.05 ± 4.13 | 2078.91 ± 809.12 | |
| F | 0.867 | 2.819 | 0.317 | 0.316 | 0.167 | 0.216 | 0.531 | 0.042 | |
| P | 0.420 | 0.060 | 0.728 | 0.729 | 0.846 | 0.806 | 0.588 | 0.959 | |
| rs2075786 | TT (n = 643) | 32.41 ± 4.75 | 21.31 ± 3.03 | 4.69 ± 3.32 | 15.55 ± 9.52 | 8.35 ± 5.40 | 5.45 ± 3.84 | 5.03 ± 5.69 | 2113.16 ± 870.60 |
| TC (n = 315) | 32.50 ± 4.82 | 21.54 ± 3.25 | 4.90 ± 3.58 | 15.50 ± 9.71 | 8.24 ± 3.79 | 5.33 ± 3.68 | 4.86 ± 3.68 | 2115.52 ± 883.38 | |
| CC (n = 27) | 33.26 ± 5.10 | 21.60 ± 2.25 | 5.00 ± 4.16 | 13.12 ± 11.47 | 8.38 ± 3.49 | 4.74 ± 2.49 | 3.77 ± 3.81 | 2159.61 ± 830.81 | |
| F | 0.417 | 0.674 | 0.471 | 0.797 | 0.059 | 0.511 | 0.679 | 0.035 | |
| P | 0.859 | 0.510 | 0.625 | 0.451 | 0.943 | 0.600 | 0.507 | 0.965 | |
| rs2736100 | GG (n = 186) | 32.44 ± 4.66 | 21.67 ± 3.30 | 4.83 ± 3.30 | 15.65 ± 9.42 | 7.82 ± 2.68 | 5.33 ± 3.58 | 4.94 ± 3.84 | 2101.08 ± 860.37 |
| GT (n = 459) | 32.39 ± 4.81 | 21.20 ± 2.78 | 4.87 ± 3.71 | 15.20 ± 9.66 | 8.63 ± 6.28 | 5.54 ± 4.02 | 4.87 ± 3.82 | 2140.34 ± 889.22 | |
| TT (n = 306) | 32.61 ± 4.82 | 21.56 ± 3.17 | 4.66 ± 3.24 | 15.42 ± 9.69 | 8.27 ± 3.59 | 5.24 ± 3.50 | 5.06 ± 7.26 | 2072.44 ± 862.03 | |
| F | 0.209 | 2.198 | 0.337 | 0.141 | 1.782 | 0.600 | 0.107 | 0.561 | |
| P | 0.812 | 0.112 | 0.714 | 0.868 | 0.169 | 0.549 | 0.899 | 0.571 | |
| rs2853677 | CC (n = 161) | 32.41 ± 4.70 | 21.47 ± 3.23 | 4.83 ± 3.32 | 15.46 ± 9.47 | 7.88 ± 2.15 | 4.99 ± 3.19 | 4.59 ± 3.77 | 2146.56 ± 870.70 |
| CT (n = 596) | 32.43 ± 4.77 | 21.29 ± 3.17 | 4.86 ± 3.63 | 15.72 ± 9.99 | 8.36 ± 5.71 | 5.60 ± 4.16 | 4.96 ± 3.75 | 2090.66 ± 851.70 | |
| TT (n = 234) | 32.49 ± 4.86 | 21.61 ± 2.83 | 4.47 ± 2.96 | 14.89 ± 8.74 | 8.52 ± 3.85 | 5.14 ± 2.93 | 5.11 ± 8.06 | 2145.92 ± 920.03 | |
| F | 0.019 | 0.978 | 1.154 | 0.591 | 0.867 | 2.353 | 0.446 | 0.478 | |
| P | 0.982 | 0.376 | 0.316 | 0.554 | 0.421 | 0.096 | 0.641 | 0.620 | |
| rs2853672 | GG (n = 271) | 32.30 ± 4.77 | 21.67 ± 3.21 | 4.91 ± 3.27 | 15.50 ± 9.94 | 8.31 ± 4.69 | 5.09 ± 3.12 | 4.86 ± 3.94 | 2080.22 ± 912.65 |
| GT (n = 468) | 32.60 ± 4.79 | 21.28 ± 2.73 | 4.77 ± 3.68 | 15.42 ± 9.55 | 8.41 ± 5.66 | 5.66 ± 4.14 | 4.84 ± 3.72 | 2132.99 ± 841.71 | |
| TT (n = 215) | 32.43 ± 4.88 | 21.42 ± 3.33 | 4.63 ± 3.30 | 14.93 ± 9.38 | 8.27 ± 3.43 | 5.17 ± 3.40 | 5.25 ± 8.26 | 2103.99 ± 874.18 | |
| F | 0.367 | 1.396 | 0.407 | 0.235 | 0.069 | 2.504 | 0.451 | 0.323 | |
| P | 0.693 | 0.248 | 0.666 | 0.790 | 0.933 | 0.082 | 0.637 | 0.724 | |
| rs2853669 | TT (n = 296) | 32.18 ± 4.62 | 21.17 ± 3.11 | 4.64 ± 3.23 | 15.64 ± 9.23 | 8.36 ± 6.45 | 5.26 ± 3.71 | 4.94 ± 3.53 | 2062.50 ± 811.08 |
| TC (n = 459) | 32.60 ± 4.88 | 21.53 ± 2.88 | 4.90 ± 3.71 | 15.38 ± 9.77 | 8.30 ± 3.40 | 5.48 ± 3.72 | 5.04 ± 6.38 | 2166.46 ± 895.31 | |
| CC (n = 148) | 32.33 ± 4.89 | 21.45 ± 3.27 | 4.67 ± 3.00 | 15.22 ± 10.34 | 8.33 ± 5.86 | 5.13 ± 3.44 | 4.80 ± 4.03 | 2027.74 ± 863.49 | |
| F | 0.735 | 1.290 | 0.583 | 0.105 | 0.013 | 0.648 | 0.106 | 2.079 | |
| P | 0.480 | 0.276 | 0.558 | 0.901 | 0.987 | 0.524 | 0.900 | 0.126 | |
| rs2735940 | TT (n = 264) | 32.39 ± 4.81 | 21.58 ± 3.15 | 4.77 ± 3.31 | 15.34 ± 9.51 | 8.27 ± 4.72 | 5.25 ± 3.64 | 4.77 ± 3.83 | 2059.43 ± 908.66 |
| TC (n = 477) | 32.48 ± 4.78 | 21.25 ± 2.97 | 4.86 ± 3.64 | 15.58 ± 9.62 | 8.44 ± 5.62 | 5.59 ± 3.99 | 4.88 ± 3.77 | 2140.59 ± 859.11 | |
| CC (n = 220) | 32.37 ± 4.72 | 21.42 ± 3.31 | 4.55 ± 3.22 | 15.03 ± 9.75 | 8.24 ± 3.42 | 5.21 ± 3.38 | 5.28 ± 8.23 | 2110.45 ± 873.34 | |
| F | 0.049 | 1.002 | 0.637 | 0.230 | 0.176 | 1.053 | 0.588 | 0.726 | |
| P | 0.952 | 0.368 | 0.529 | 0.795 | 0.839 | 0.349 | 0.556 | 0.484 | |
| rs2736108 | GG (n = 444) | 32.25 ± 4.67 | 21.26 ± 3.04 | 4.66 ± 3.35 | 15.86 ± 9.67 | 8.33 ± 5.84 | 5.34 ± 3.67 | 5.29 ± 6.34 | 2050.23 ± 844.89 |
| GA (n = 434) | 32.62 ± 4.77 | 21.51 ± 3.16 | 4.93 ± 3.62 | 15.53 ± 9.91 | 8.42 ± 4.08 | 5.61 ± 3.99 | 4.77 ± 3.82 | 2171.63 ± 906.17 | |
| AA (n = 108) | 32.31 ± 5.17 | 21.48 ± 3.13 | 4.43 ± 2.92 | 13.88 ± 8.03 | 7.56 ± 1.96 | 4.71 ± 3.13 | 4.23 ± 3.40 | 2146.23 ± 820.42 | |
| F | 0.695 | 0.717 | 1.190 | 1.714 | 1.418 | 2.495 | 2.090 | 2.201 | |
| P | 0.499 | 0.488 | 0.305 | 0.181 | 0.243 | 0.083 | 0.124 | 0.111 |
Clinical indices were expressed as the mean ± standard deviation and compared using analysis of variance. Three genotypes of each polymorphism showed no significant differences in terms of woman’s age, duration of infertility, BMI, AFC, basal FSH, basal LH, basal E2, AMH or total dose of Gn
BMI body mass index, AFC antral follicle count, bFSH basal follicle-stimulating hormone, bLH basal luteinizing hormone, AMH anti-Mullerian hormone, F statistics for the analysis of variance
P <0.01 was considered statistically significant