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. 2018 Dec 10;36(3):517–527. doi: 10.1007/s10815-018-1379-y

Table 3.

Laboratory parameters of three genotypes in every hTERT SNP

SNP Genotypes (no.) Oocytes (n) Mature oocytes (n) 2PN fertilisation rate (%) Cleavage rate (%) Embryos available (n) Good-quality embryos (n)
rs2853691 AA (n = 590) 11.57 ± 6.99 9.86 ± 6.04 64.72 ± 22.25 95.72 ± 14.13 5.31 ± 3.82 2.28 ± 2.65
AG (n = 327) 11.55 ± 6.68 9.86 ± 5.83 64.57 ± 20.83 95.97 ± 13.93 5.53 ± 4.30 2.58 ± 3.09
GG (n = 32) 10.91 ± 6.57 9.34 ± 5.20 69.90 ± 16.35 96.53 ± 13.43 5.22 ± 2.87 1.59 ± 1.48
AA+AG (n = 917) 11.56 ± 6.89 9.86 ± 5.96 64.67 ± 21.74 95.81 ± 14.04 5.39 ± 4.00 2.39 ± 2.82
GG+AG (n = 359) 11.49 ± 6.67 9.81 ± 5.78 64.59 ± 19.73 96.02 ± 13.86 5.50 ± 4.19 2.50 ± 3.00
F 0.141 0.116 0.914 0.074 0.335 2.494
P 0.869 0.890 0.401 0.929 0.716 0.083
P’ (AA+AG vs GG) 0.597 0.629 0.178 0.774 0.805 0.112
P” (GG+AG vs AA) 0.863 0.887 0.215 0.75 0.484 0.238
rs2075786 TT (n = 643) 11.73 ± 6.86 10.02 ± 6.00 64.97 ± 21.68 95.81 ± 14.98 5.42 ± 3.96 2.35 ± 2.75
TC (n = 315) 11.77 ± 6.95 10.04 ± 6.05 65.23 ± 20.98 96.08 ± 11.57 5.62 ± 4.08 2.52 ± 2.81
CC (n = 27) 10.74 ± 7.74 9.30 ± 6.12 63.63 ± 22.36 97.92 ± 4.76 4.69 ± 3.11 1.48 ± 1.57
TT+TC (n = 958) 11.74 ± 6.89 10.03 ± 6.01 65.05 ± 21.44 95.90 ± 13.95 5.49 ± 4.00 2.41 ± 2.78
CC+TC (n = 342) 11.69 ± 7.02 9.99 ± 6.05 65.10 ± 21.67 96.23 ± 11.2 5.55 ± 4.02 2.44 ± 2.75
F 0.278 0.196 0.071 0.314 0.768 0.023
P 0.757 0.822 0.932 0.731 0.464 0.977
P’ (TT+TC vs CC) 0.458 0.532 0.738 0.460 0.316 0.006
P” (CC+TC vs TT) 0.927 0.925 0.433 0.654 0.631 0.609
rs2736100 GG (n = 186) 11.98 ± 7.34 10.07 ± 6.45 62.35 ± 22.31 96.88 ± 9.92 5.44 ± 4.07 2.41 ± 2.86
GT (n = 459) 11.36 ± 6.85 9.76 ± 6.05 65.69 ± 21.67 94.82 ± 16.67 5.24 ± 3.83 2.20 ± 2.62
TT (n = 306) 11.66 ± 6.69 9.89 ± 5.53 64.71 ± 20.97 96.87 ± 11.37 5.63 ± 4.14 2.59 ± 2.96
GG+GT (n = 645) 11.54 ± 6.99 9.85 ± 6.17 64.72 ± 21.39 95.41 ± 15.07 5.30 ± 3.90 2.26 ± 2.69
TT+GT (n = 765) 11.48 ± 6.79 9.81 ± 5.84 65.30 ± 21.39 95.64 ± 14.82 5.39 ± 3.96 2.36 ± 2.76
F 0.559 0.182 1.567 2.541 0.894 1.871
P 0.572 0.834 0.209 0.079 0.409 0.155
P’ (GG+GT vs TT) 0.807 0.94 0.264 0.135 0.23 0.084
P” (TT+GT vs GG) 0.377 0.591 0.097 0.281 0.880 0.825
rs2853677 CC (n = 161) 12.05 ± 7.92 10.27 ± 7.16 62.78 ± 21.55 94.93 ± 15.08 5.35 ± 4.21 2.32 ± 2.86
CT (n = 596) 12.03 ± 6.91 10.31 ± 5.87 66.49 ± 21.01 96.35 ± 13.56 5.71 ± 4.04 2.48 ± 2.80
TT (n = 234) 10.76 ± 6.07 9.08 ± 5.39 62.50 ± 22.24 95.65 ± 13.29 4.91 ± 3.57 2.21 ± 2.57
CC+CT (n = 757) 12.03 ± 7.13 10.30 ± 6.16 65.71 ± 21.16 96.05 ± 13.90 5.63 ± 4.08 2.45 ± 2.81
TT+CT (n = 830) 11.67 ± 6.70 9.96 ± 5.76 65.36 ± 21.63 96.16 ± 13.48 5.48 ± 3.93 2.39 ± 2.76
F 3.041 3.702 3.850 0.741 3.304 0.898
P 0.048 0.025 0.022 0.477 0.037 0.408
P’ (CC+CT vs TT) 0.008 0.004 0.047 0.699 0.011 0.248
P” (TT+CT vs CC) 0.525 0.547 0.669 0.305 0.711 0.707
rs2853672 GG (n = 271) 11.68 ± 7.48 9.82 ± 6.55 63.58 ± 23.07 95.16 ± 15.03 5.31 ± 4.14 2.27 ± 2.80
GT (n = 468) 11.52 ± 6.71 10.00 ± 5.88 65.80 ± 21.17 95.49 ± 15.76 5.40 ± 3.83 2.34 ± 2.63
TT (n = 215) 11.57 ± 6.53 9.71 ± 5.36 64.59 ± 20.44 97.61 ± 6.26 5.55 ± 4.09 2.55 ± 3.06
GG+GT (n = 739) 11.58 ± 7.00 9.93 ± 6.13 64.99 ± 21.89 95.37 ± 15.49 5.37 ± 3.94 2.31 ± 2.69
TT+GT (n = 683) 11.54 ± 6.65 9.91 ± 5.72 65.42 ± 20.81 96.15 ± 13.55 5.45 ± 3.91 2.41 ± 2.78
F 0.046 0.204 0.930 2.176 0.219 0.685
P 0.955 0.815 0.395 0.114 0.803 0.505
P’ (GG+GT vs TT) 0.978 0.624 0.812 0.002 0.552 0.264
P” (TT+GT vs GG) 0.769 0.827 0.889 0.324 0.634 0.479
rs2853669 TT (n = 296) 11.92 ± 6.43 10.15 ± 5.50 65.22 ± 21.18 97.25 ± 8.44 5.59 ± 3.94 2.56 ± 2.90
TC (n = 459) 11.61 ± 7.25 9.99 ± 6.29 65.03 ± 21.17 95.83 ± 14.44 5.42 ± 4.05 2.27 ± 2.71
CC (n = 148) 11.42 ± 6.76 9.47 ± 5.98 63.23 ± 24.28 94.23 ± 18.83 5.27 ± 3.89 2.45 ± 2.87
TT+TC (n = 755) 11.73 ± 6.93 10.05 ± 5.99 65.11 ± 21.16 96.39 ± 12.44 5.49 ± 4.01 2.38 ± 2.79
CC+TC (n = 607) 11.57 ± 7.13 9.86 ± 6.21 64.59 ± 22.73 95.44 ± 15.62 5.39 ± 4.01 2.31 ± 2.75
F 0.303 0.657 0.463 2.491 0.326 1.017
P 0.739 0.519 0.630 0.083 0.722 0.362
P’ (TT+TC vs CC) 0.612 0.275 0.385 0.185 0.556 0.773
P” (CC+TC vs TT) 0.472 0.504 0.99 0.063 0.479 0.215
rs2735940 TT (n = 264) 11.52 ± 7.30 9.89 ± 6.41 63.56 ± 22.86 95.73 ± 13.85 5.26 ± 4.13 2.30 ± 2.83
TC (n = 477) 11.68 ± 6.79 10.09 ± 5.92 65.56 ± 21.11 95.16 ± 16.31 5.46 ± 3.86 2.34 ± 2.61
CC (n = 220) 11.65 ± 6.66 9.84 ± 5.53 64.92 ± 20.81 97.66 ± 6.20 5.57 ± 4.10 2.58 ± 3.06
TT+TC (n = 741) 11.62 ± 6.97 9.94 ± 6.10 64.85 ± 21.75 95.36 ± 15.48 5.39 ± 3.95 2.32 ± 2.69
CC+TC (n = 697) 11.67 ± 6.75 10.01 ± 5.80 65.36 ± 20.97 95.95 ± 13.98 5.49 ± 3.94 2.41 ± 2.76
F 0.044 0.408 0.722 2.433 0.374 0.746
P 0.957 0.665 0.486 0.088 0.688 0.475
P’ (TT+TC vs CC) 0.950 0.816 0.964 0.032 0.556 0.227
P” (CC+TC vs TT) 0.768 0.457 0.471 0.827 0.427 0.566
rs2736108 GG (n = 444) 11.78 ± 6.41 10.09 ± 5.48 65.72 ± 20.47 96.89 ± 10.98 5.63 ± 3.84 2.54 ± 2.84
GA (n = 434) 11.83 ± 7.33 10.09 ± 6.39 64.91 ± 21.68 95.48 ± 15.23 5.40 ± 4.14 2.23 ± 2.60
AA (n = 108) 11.26 ± 7.05 9.46 ± 6.39 61.55 ± 24.05 93.98 ± 17.48 5.17 ± 3.89 2.50 ± 2.99
GG+GA (n = 878) 11.80 ± 6.88 10.09 ± 5.94 65.32 ± 21.07 96.19 ± 13.26 5.52 ± 3.99 2.39 ± 2.73
AA+GA (n = 542) 11.71 ± 7.27 9.97 ± 6.39 64.24 ± 22.87 95.18 ± 15.70 5.36 ± 4.09 2.28 ± 2.69
F 0.303 0.530 1.616 2.367 0.712 1.487
P 0.738 0.589 0.199 0.094 0.491 0.227
P’ (GG+GA vs AA) 0.440 0.303 0.125 0.211 0.398 0.686
P” (GG+GA vs GG) 0.887 0.752 0.86 0.054 0.286 0.144

2PN fertilisation rate was calculated by number of two-pronuclei/number of oocytes retrieved when IVF cycles were performed or number of two-pronuclei/number of metaphase II oocytes when ICSI cycles were performed. Cleavage rate was calculated by number of cleavages/number of oocytes retrieved when IVF cycles were performed or number of cleavages/number of metaphase II oocytes when ICSI cycles were performed. Laboratory parameters were expressed as the mean ± standard deviation and compared using analysis of variance. Statistically significant differences are shown in italics

F statistics for the analysis of variance

P < 0.01 was considered statistically significant