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. 2018 Dec 10;36(3):517–527. doi: 10.1007/s10815-018-1379-y

Table 4.

Laboratory parameters of three genotypes in every hTERT SNP in patients ≤ 35 years

SNP Genotypes (no.) Oocytes (n) Mature oocytes (n) 2PN fertilisation rate (%) Cleavage rate (%) Embryos available (n) Good-quality embryos (n)
rs2853691 AA (n = 449) 12.69 ± 6.87 10.80 ± 5.97 64.48 ± 21.11 95.82 ± 14.13 5.73 ± 3.93 2.51 ± 2.76
AG (n = 241) 12.58 ± 6.56 10.72 ± 5.64 64.45 ± 18.95 96.99 ± 9.49 5.92 ± 4.36 2.79 ± 3.09
GG (n = 24) 12.25 ± 6.80 10.42 ± 5.22 67.32 ± 13.25 95.38 ± 15.41 5.67 ± 3.06 1.58 ± 1.47
AA+AG (n = 690) 12.65 ± 6.76 10.77 ± 5.85 64.47 ± 20.37 96.23 ± 12.71 5.80 ± 4.08 2.61 ± 2.88
GG+AG (n = 265) 12.55 ± 6.57 10.69 ± 5.60 64.71 ± 16.20 96.84 ± 10.14 5.89 ± 4.25 2.68 ± 3
F 0.060 0.058 0.230 0.698 0.176 2.296
P 0.941 0.944 0.794 0.498 0.839 0.101
P’ (AA+AG vs GG) 0.775 0.770 0.321 0.749 0.842 0.003
P” (GG+AG vs AA) 0.818 0.822 0.105 0.308 0.589 0.39
rs2075786 TT (n = 482) 12.68 ± 6.79 10.76 ± 5.96 64.20 ± 20.62 96.12 ± 13.79 5.78 ± 4.06 2.52 ± 2.78
TC (n = 240) 13.15 ± 6.91 11.26 ± 5.90 66.08 ± 19.33 96.60 ± 10.25 6.14 ± 4.15 2.82 ± 2.92
CC (n = 19) 11.32 ± 6.05 10.21 ± 5.69 63.09 ± 17.65 97.40 ± 5.46 5.39 ± 3.24 1.47 ± 1.42
TT+TC (n = 722) 12.84 ± 6.83 10.93 ± 5.94 64.83 ± 20.21 96.28 ± 12.72 5.90 ± 4.09 2.62 ± 2.83
CC+TC (n = 259) 13.02 ± 6.86 11.19 ± 5.88 65.86 ± 18.49 96.65 ± 9.99 6.09 ± 4.09 2.72 ± 2.87
F 0.841 0.715 0.765 0.187 0.783 2.453
P 0.432 0.489 0.466 0.830 0.457 0.087
P’ (TT+TC vs CC) 0.337 0.604 0.717 0.709 0.601 0.003
P” (CC+TC vs TT) 0.524 0.349 0.69 0.58 0.319 0.362
rs2736100 GG (n = 142) 13.06 ± 7.18 10.85 ± 6.41 60.64 ± 20.72 96.32 ± 10.98 5.66 ± 4.11 2.55 ± 2.89
GT (n = 349) 12.56 ± 6.74 10.84 ± 6.01 65.77 ± 20.10 95.67 ± 14.53 5.68 ± 3.97 2.43 ± 2.76
TT (n = 227) 12.66 ± 6.57 10.68 ± 5.25 64.94 ± 19.80 97.17 ± 10.68 6.14 ± 4.19 2.82 ± 2.90
GG+GT (n = 491) 12.71 ± 6.87 10.85 ± 6.12 64.29 ± 19.97 95.85 ± 13.59 5.67 ± 4.00 2.47 ± 2.80
GT+TT (n = 576) 12.60 ± 6.67 10.78 ± 5.72 65.44 ± 19.97 96.26 ± 13.16 5.86 ± 4.06 2.59 ± 2.83
F 0.281 0.060 3.347 0.948 1.035 1.319
P 0.755 0.942 0.036 0.388 0.356 0.268
P’ (GG+GT vs TT) 0.926 0.73 0.329 0.201 0.15 0.117
P” (GT+TT vs GG) 0.464 0.895 0.011 0.961 0.602 0.888
rs2853677 CC (n = 124) 13.37 ± 8.02 11.30 ± 7.32 62.14 ± 20.35 94.88 ± 14.33 5.65 ± 4.36 2.47 ± 2.92
CT (n = 447) 13.07 ± 6.74 11.16 ± 5.69 65.99 ± 19.90 96.64 ± 12.78 6.14 ± 4.11 2.68 ± 2.81
TT (n = 177) 11.79 ± 5.93 9.99 ± 5.26 63.28 ± 20.41 96.48 ± 10.40 5.36 ± 3.68 2.48 ± 2.71
CC+CT (n = 571) 13.13 ± 7.03 11.19 ± 6.08 65.17 ± 20.04 96.26 ± 13.14 6.04 ± 4.17 2.64 ± 2.84
TT+CT (n = 624) 12.71 ± 6.54 10.83 ± 5.6 65.22 ± 20.16 96.60 ± 12.15 5.92 ± 4.01 2.63 ± 2.79
F 2.736 2.829 2.369 0.972 2.515 0.475
P 0.065 0.060 0.094 0.379 0.082 0.622
P’ (CC+CT vs TT) 0.012 0.011 0.277 0.840 0.056 0.536
P” (TT+CT vs CC) 0.32 0.42 0.578 0.166 0.515 0.565
rs2853672 GG (n = 204) 12.81 ± 7.48 10.66 ± 6.62 62.38 ± 22.16 95.00 ± 15.27 5.58 ± 4.26 2.40 ± 2.87
GT (n = 355) 12.76 ± 6.56 11.13 ± 5.73 66.36 ± 18.95 96.28 ± 13.38 5.95 ± 3.92 2.63 ± 2.75
TT (n = 159) 12.36 ± 6.33 10.27 ± 5.04 63.52 ± 19.72 97.78 ± 5.73 5.83 ± 4.11 2.70 ± 2.98
GG+GT (n = 559) 12.78 ± 6.90 10.96 ± 6.07 64.91 ± 20.25 95.81 ± 14.09 5.82 ± 4.05 2.55 ± 2.80
TT+GT (n = 514) 12.63 ± 6.49 10.87 ± 5.53 65.48 ± 19.34 96.74 ± 11.59 5.92 ± 3.98 2.65 ± 2.83
F 0.241 1.282 2.828 2.114 0.562 0.589
P 0.786 0.278 0.060 0.122 0.570 0.555
P’ (GG+GT vs TT) 0.491 0.191 0.444 0.087 0.960 0.551
P” (TT+GT vs GG) 0.749 0.667 0.929 0.10 0.31 0.292
rs2853669 TT (n = 228) 12.68 ± 6.31 10.75 ± 5.33 64.77 ± 20.03 97.53 ± 6.10 5.87 ± 3.93 2.66 ± 2.83
TC (n = 344) 13.00 ± 7.14 11.22 ± 6.20 65.18 ± 19.02 97.02 ± 10.79 5.98 ± 4.21 2.57 ± 2.88
CC (n = 111) 12.28 ± 6.52 10.00 ± 5.78 61.73 ± 23.49 92.51 ± 21.31 5.37 ± 3.83 2.50 ± 2.81
TT+TC (n = 572) 12.87 ± 6.82 11.04 ± 5.87 65.01 ± 19.41 97.22 ± 9.21 5.94 ± 4.10 2.60 ± 2.86
CC+TC (n = 455) 12.82 ± 6.99 10.92 ± 6.12 64.34 ± 21.26 95.92 ± 14.22 5.83 ± 4.13 2.55 ± 2.86
F 0.508 1.887 1.260 7.236 0.947 0.123
P 0.602 0.152 0.284 0.001 a 0.389 0.884
P’ (TT+TC vs CC) 0.397 0.089 0.169 0.001 0.180 0.734
P” (CC+TC vs TT) 0.799 0.723 0.689 0.104 0.894 0.653
rs2735940 TT (n = 197) 12.68 ± 7.39 10.53 ± 6.54 62.01 ± 21.86 95.24 ± 15.34 5.56 ± 4.30 2.47 ± 2.91
TC (n = 364) 12.90 ± 6.56 11.20 ± 5.73 66.36 ± 18.99 96.16 ± 13.36 5.99 ± 3.93 2.62 ± 2.73
CC (n = 166) 12.34 ± 6.55 10.34 ± 5.30 64.14 ± 20.28 97.80 ± 5.67 5.81 ± 4.11 2.68 ± 2.96
TT+TC (n = 561) 12.82 ± 6.86 10.97 ± 6.03 64.83 ± 20.13 95.84 ± 14.08 5.84 ± 4.07 2.57 ± 2.79
CC+TC (n = 530) 12.73 ± 6.55 10.93 ± 5.61 65.67 ± 19.64 96.67 ± 11.55 5.93 ± 3.99 2.64 ± 2.8
F 0.388 1.549 3.063 1.853 0.704 0.276
P 0.679 0.213 0.047 0.157 0.495 0.759
P’ (TT+TC vs CC) 0.424 0.230 0.697 0.087 0.940 0.654
P” (CC+TC vs TT) 0.935 0.416 0.523 0.179 0.275 0.479
rs2736108 GG (n = 342) 12.58 ± 6.31 10.73 ± 5.31 65.38 ± 19.74 97.29 ± 9.29 5.96 ± 3.86 2.68 ± 2.80
GA (n = 323) 13.23 ± 7.26 11.30 ± 6.40 65.01 ± 19.60 96.20 ± 13.11 5.96 ± 4.35 2.56 ± 2.81
AA (n = 80) 12.05 ± 6.84 10.01 ± 6.20 61.05 ± 23.63 92.58 ± 19.83 5.29 ± 3.74 2.50 ± 2.86
GG+GA (n = 665) 12.90 ± 6.79 11.01 ± 5.87 65.20 ± 19.66 96.76 ± 11.32 5.96 ± 4.10 2.62 ± 2.81
AA+GA (n = 403) 13.00 ± 7.19 11.04 ± 6.38 64.22 ± 21.62 95.48 ± 14.74 5.83 ± 4.24 2.55 ± 2.82
F 1.345 1.770 1.541 4.615 0.986 0.227
P 0.261 0.171 0.215 0.010 d 0.374 0.797
P’ (GG+GA vs AA) 0.292 0.155 0.135 0.005 0.160 0.716
P” (AA+GA vs GG) 0.394 0.478 0.534 0.051 0.649 0.513

Laboratory parameters were expressed as the mean ± standard deviation and compared using analysis of variance. Pairwise comparisons of the indices between every two genotypes were conducted using the Bonferroni test

F statistics for the analysis of variance

P < 0.01 was considered statistically significant

aFor the polymorphism rs2853669 T>C, the patients with the CC genotype exhibited a lower cleavage rate than those with the TT (P = 0.001) or TC (P = 0.002) genotypes

bFor the polymorphism rs2736108 G>A, the patients with the AA genotype had a significantly lower cleavage rate than those with the GG genotype (P = 0.008)