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| Key factors | Main sources | Function | |
|---|---|---|---|
| Type 2 immunity | |||
| IL-5 | Th2/ILC2 | Increase eosinophil activation/survival | |
| CysLT overproduction | |||
| LTE4 | Eosinophils | Elevate eosinophil accumulation | |
| Induce smooth muscle constriction | |||
| Eosinophil-epithelium interaction | |||
| Extracellular traps/vesicles | Eosinophils | Enhance airway inflammation | |
