Table 3.
WM regions where a higher frequency of WML was associated with worst scores of cognitive tests in our sample of VMCI patients (p < .01, corrected for multiple comparisons across space). Correlation analyses were controlled for age, sex, FLAIR slice thickness, center, magnetic field strength, total LV (in native space) and head size.
| Test (cognitive domain) | WM tract | Type of WM tract | Lobe | Side | MNI X,Y,Z (mm)⁎ | Cluster size (voxel count) | P-value |
|---|---|---|---|---|---|---|---|
| TMT-A (psychomotor speed) | ILF | Association | Occipital | R | 36, −62, 9 | 1110 | <0.001 |
| IFOF | Association | Occipital | R | 25,-92,4 | 326 | 0.003 | |
| SLF (angular gyrus) | Association | Occipital | L | −40,-61,21 | 262 | 0.006 | |
| SLF (superior parietal lobule) | Association | Parietal | L | −24,-50,59 | 148 | 0.007 | |
| ILF | Association | Occipital | L | −25,-70,20 | 104 | 0.005 | |
| ILF | Association | Occipital | L | −37,-63,9 | 57 | 0.006 | |
| SLF (angular gyrus) |
Association | Parietal | R | 50,-53,36 | 45 | 0.006 | |
| ROCF-copy (constructional praxis) | IFOF | Association | Temporal | L | −35,-51,-2 | 28 | 0.009 |
| IFOF | Association | Temporal | L | −38,-39,-4 | 12 | 0.009 |
⁎
Local maxima of significant cluster.