Table 4.
WM regions with differences in lesion frequency among the cognitive groups of VMCI (p < .01, corrected): amnestic single-domain (ASD), amnestic multi-domain (AMD), non-amnestic single-domain (NASD) and non-amnestic multi-domain (NAMD). Comparison analyses were controlled for age, sex, FLAIR slice thickness, center, magnetic field strength, total LV (in native space) and head size.
| Group comparison | WM tract | Type of WM tract | Lobe | Side | MNI X,Y,Z (mm)⁎ | Cluster size (voxel count) | P-value |
|---|---|---|---|---|---|---|---|
| NA (SD + MD) > A (SD + MD) | Cg | Association | Frontal | R | 13,14,43 | 18 | 0.001 |
| NAMD > NASD | SLF (IFG) | Association | Frontal | R | 31,4,27 | 23 | 0.002 |
| NAMD > AMD | Cg | Association | Frontal | R | 13,14,43 | 27 | <0.001 |
| SLF (MFG) | Association | Frontal | R | 38,5,31 | 24 | 0.001 |
⁎
Local maxima of significant cluster.