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. 2019 Mar 27;21(4):413–427. doi: 10.1016/j.neo.2019.03.003

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Figure S3 — LOXL2 promotes the invasion and tube formation of LECs. (A) Quantified results showing the relative proliferation of the hLECs treated with LOXL2 protein. (B) The mRNA levels of LOXL2 in the indicated cells were measured by qRT-PCR. (C) The protein levels of LOXL2 in the indicated cells and CM were measured by immunoblot using LOXL2 (ab96233) antibody. (D) The mRNA levels of LOX, LOXL1, LOXL3, LOXL4 in the MCF7-LOXL2, MDA231-shLOXL2 cells and their corresponding controls (MCF7-LV, MDA231-LV) were measured by RT-qPCR. (E, F) Representative results showing the invasion and tube formation activity of the hLECs treated with CM from the MCF7-LOXL2, MDA231-shLOXL2 and their corresponding controls (MCF7-LV, MDA231-LV). (G, H) Quantified results showing the relative invasion and tube formation activity of the mLECs treated with MCF7-LV CM or MCF7-LOXL2 CM in the presence of IgG or LOXL2-antibodies. Quantified results showing the relative invasion and tube formation activity of the hLECs treated with MDA231-LV CM or MDA231-shLOXL2 CM in the presence of LOXL2 or BSA. The data are the means ± SD of three independent experiments. *P < .05; **P < .01; ***P < .001.