Fig. 5.

Structural determinants of cysteine-mediated redox sensing. A, Overrepresented InterPro domains in thermal shifted proteins. The domains appearing in at least three target proteins are included for visualization in the graph, and proteins are clustered based on the pattern of containing domains. B, Histogram (left) and violin plot (right) of the composition percentage of cysteines in Hit and Base proteins. Statistical significance was calculated with two sample t-tests. C, Boxplot of pKa value (left) and solvent accessibility area (right) of cysteines in Hit and Base protein groups. Statistical significance was calculated with two sample t-tests.