FIGURE 5.

Validation of expression levels of FOS and other genes involved in the amphetamine pathway in GEO datasets GSE73129, GSE92538, and GSE10784. The expression of FOS, FOSB, JUN, PRKCA, GRIA3, and CALM3 between schizophrenia and control lymphoblast samples have been presented in the histograms. MRNA expression level means the intensity of the detected fluorescence intensity transformed by log₂. NS indicates not significant, ^∗ indicates p-value < 0.05, ^∗∗ indicates p-value < 0.01, ^∗∗∗indicates p-value < 0.001. (A) Expression levels of FOS and other genes involved in the amphetamine pathway between schizophrenia and control lymphoblast samples in GEO dataset GSE73129. (B) Expression levels of FOS and other genes involved in the amphetamine pathway in human post-mortem dorsolateral prefrontal cortex samples from UCDavis or UMichigan. Samples were collected from schizophrenia patients and healthy controls. (C) FOS and other genes involved in the amphetamine pathway expression changes in the prefrontal cortex (PFC) and hippocampus (HPC) of the Df(16)A+/– schizophrenia mouse model.