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. 2019 Mar 22;10:230. doi: 10.3389/fgene.2019.00230

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Copyright © 2019 Alexandre, Naval-Sanchez, Porto-Neto, Ferraz, Reverter and Fukumasu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genes selected for co-expression network construction. (A) Heatmap of normalized mean expression (NME) of 471 differentially expressed (DE) genes between high (HFE) and low (LFE) feed efficient animals in adrenal gland (ADR), hypothalamus (HYP), liver (LIV), muscle (MUS) and pituitary (PIT). Genes (rows) and samples (columns) are organized by hierarchical clustering based on Euclidean distances. (B) NME heatmap of all 1,335 genes selected for network construction. Genes (columns) and samples (rows) are organized by hierarchical clustering based on Euclidean distances. (C) Venn diagram of 1,335 genes selected for network construction. The inclusion criteria for selecting genes were divided into five categories: differentially expressed genes (DE), tissue specific genes (TS), genes harboring SNPs reported in literature as being associated with feed efficiency in beef cattle (SNP), genes encoding proteins secreted by at least one of the tissues in plasma (SEC) and key regulators (REG). Numbers between brackets indicate the total number of genes in each category.