Table 1.
Tumor volumes (mm3) of mice (n = 8 per group) of control (ctrl) and treatment groups (NK, PD-1, NK + PD-1).
| Day 5 | Day 10 | Day 15 | Day 20 | Day 25 | Day 30 | |
|---|---|---|---|---|---|---|
| PBS (ctrl) | 29 (3) | 178.67 (12.22) | ||||
| IgG (ctrl) | 27.33 (9.50) | 202.67 (11.93) | ||||
| NK | 23.33 (5.13) | 66.33 (11.15) | 104.33 (30.43) | 203.67 (33.29) | ||
| PD-1 | 28 (14.52) | 47.33 (9.02) | 80 (18.08) | 100.67 (23.46) | 205.33 (23.80) | |
| NK + PD-1 | 26.67 (7.77) | 44.66 (8.02) | 57.33 (9.71) | 73 (9.54) | 87.33 (9.29) | 124.33 (22.12) |
Sham treatment: PBS (ctrl, 100 μl, iv), IgG (ctrl, 500 μl, ip) isotype-matched control antibody; treatment: NK, ex vivo TKD/IL-2-activated NK cells (6x106 cells in 100 μl PBS, iv); PD-1, PD-1 antibody (500 μl, ip); NK + PD-1, ex vivo activated NK cells (6x106 cells in 100 μl PBS, iv) + PD-1 (500 μl, ip) antibody over 6 time points (days 5, 10, 15, 20, 25, 30). The data represent mean values ± SD.