Table 3.
Number of tumor-infiltrating CD8+ T cells, NK1.1 cells and PD-1+ expressing effector cells in tumor sections of mice of the sham-treated control (ctrl) and treatment groups (NK, PD-1, NK+PD-1).
| NK 1.1 cells | CD8 cells | PD-1+ cells | |
|---|---|---|---|
| PBS (ctrl) | 7 (3.61) | 6.33 (2.08) | 53.67 (9.71) |
| IgG (ctrl) | 5 (1) | 7.67 (1.53) | 53.67 (5.03) |
| PD-1 | 30.33 (7.77) | 17.33 (3.06) | 16.67 (4.16) |
| NK | 19.67 (8.02) | 14.67 (3.51) | 34.67 (5.13) |
| NK + PD-1 | 40.33 (4.62) | 22.22 (3.51) | 12.67 (5.51) |
Sham-treated groups: PBS (ctrl), PBS (100 μl, iv), IgG (ctrl), isotype-matched IgG control antibody (500 μl, ip). Treated groups: NK, ex vivo activated NK cells (6x106 cells in 100 μl PBS, iv), PD-1, PD-1 antibody (500 μl, ip), NK+PD-1, ex vivo activated NK cells (6x106 cells in 100 μl PBS, iv) + PD-1 antibody (500 μl, ip). The data represent mean values of three fields of view ± SD.