Table 5.
Number of tumor-infiltrating CD8+ T cells, CD56+ NK cells and PD-1+ expressing effector cells in A549 lung carcinoma sections of mice of the sham-treated control (ctrl) and treatment groups (NK, PD-1, NK+PD-1).
| Cell type | |||
|---|---|---|---|
| Treatment | CD56+ NK cells | CD8+ cells | PD-1+ cells |
| PBS (ctrl) | 4.67 (1.53) | 6.00 (1.73) | 59.00 (3.00) |
| IgG (ctrl) | 6.00 (2.00) | 10.00 (2.00) | 55.67 (10.02) |
| NK | 24.67 (11.59) | 20.00 (1.00) | 33.33 (5.86) |
| NK + PD-1 | 45.67 (6.11) | 44.33 (10.02) | 8.00 (2.00) |
Sham-treated groups: PBS (ctrl), PBS (100 μl, iv), IgG (ctrl), isotype-matched IgG control antibody (500 μl, ip). Treated groups: NK, ex vivo activated NK cells (6 × 106 cells in 100 μl PBS, iv), ex vivo activated NK cells (6 × 106 cells in 100 μl PBS, iv) + PD-1 antibody (500 μl, ip). The data represent mean values of three fields of view ± SD.