Table 1.

Summary of the main S. cerevisiae models for amyloid-associated diseases.

Disease	Main aggregative moiety	Mode of gene expression	Representative candidate drugs	Candidate drugs validation in multicellular organism	Representative toxicity modifiers from genetic screens (mammalian homologs)	References
Huntington's Disease	Poly Q	Exogenous	EGCG Actinomycin D C2-8	Human cultured cells Rodents Drosophila	Bna4 (kynurenine 3-mononygenase)	Krobitsch and Lindquist, 2000; Giorgini et al., 2005; Zhang et al., 2005; Ehrnhoefer et al., 2006; Walter et al., 2014; Hofer et al., 2018
Amyotrophic Lateral Sclerosis	SOD1 FUS TDP-43	Exogenous	8-Hydroxyquinolines	_	Pbp1 (Ataxin-2)	Armakola et al., 2011; Ju et al., 2011; Tardiff et al., 2012; Martins and English, 2014; Di Gregorio and Duennwald, 2018
Alzheimer's Disease	Aβ42 Tau	Exogenous	Latrepirdine Clioquinol Dihydropyrimidine-Thiones	Human cultured cells Rodents Nematodes	Yap1801/2 (PICALM)	Vandebroek et al., 2005; Doody et al., 2008; Treusch et al., 2011; Barr et al., 2012; Steele et al., 2013; Amen and Kaganovich, 2016; Park et al., 2016; Seynnaeve et al., 2018
Parkinson's Disease	α-Synuclein	Exogenous	1,2,4-oxadiazoles N-aryl Benzimidazole	Human cultured cells	Rab1 (Ypt1)	Outeiro and Lindquist, 2003; Bhullar et al., 2006; Chung et al., 2013; Tardiff et al., 2013; Vincent et al., 2018
Type 2 Diabetes	IAPP	Exogenous	_	_	Ste24 (ZMPSTE24)	Kayatekin et al., 2018
IEM disorders related to adenine accumulation	Adenine	Endogenous	_	_	_	Laor et al., 2019