Table 4.
The Prognostic values of E2F family members in all and different pathological subtypes OC patients (Kaplan-Meier plotter).
| E2F family | Histology | OS | PFS | PPS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | HR | 95% CI | p-value | Cases | HR | 95% CI | p-value | Cases | HR | 95% CI | p-value | ||
| E2F1 | Overall | 1,656 | 1.10 | 0.96–1.25 | 0.16 | 1,435 | 0.91 | 0.80–1.04 | 0.17 | 782 | 1.23 | 1.02–1.48 | 0.03 |
| 204947_at | Serous | 1,207 | 1.18 | 1.00–1.39 | 0.05 | 1,104 | 1.06 | 0.90–1.26 | 0.47 | 735 | 1.22 | 1.01–1.49 | 0.04 |
| Endometrioid | 37 | — | — | 0.07 | 51 | 6.12 | 1.4–26.69 | 0.01 | 14 | — | — | — | |
| E2F2 | Overall | 1,656 | 0.90 | 0.79–1.02 | 0.10 | 1,435 | 0.88 | 0.78–1 | 0.06 | 782 | 1.22 | 1.02–1.46 | 0.03 |
| 207042_at | Serous | 1,207 | 0.80 | 0.68–0.95 | 0.01 | 1,104 | 1.17 | 1–1.36 | 0.05 | 735 | 1.20 | 1–1.45 | 0.05 |
| Endometrioid | 37 | 0.16 | 51 | 0.33 | 0.12–0.9 | 0.02 | 14 | — | — | — | |||
| E2F3 | Overall | 1,656 | 1.11 | 0.97–1.26 | 0.12 | 1,435 | 1.08 | 0.93–1.25 | 0.32 | 782 | 1.13 | 0.95–1.33 | 0.17 |
| 203692_s_at | Serous | 1,207 | 1.18 | 1.00–1.39 | 0.05 | 1,104 | 0.89 | 0.77–1.03 | 0.13 | 735 | 1.20 | 1–1.42 | 0.05 |
| Endometrioid | 37 | 2.68 | 0.45–16.08 | 0.26 | 51 | 8.63 | 1.15–64.93 | 0.01 | 14 | — | — | — | |
| E2F4 | Overall | 1,656 | 0.93 | 0.81–1.07 | 0.31 | 1,435 | 0.82 | 0.71–0.94 | 0.00 | 782 | 1.24 | 1.04–1.48 | 0.02 |
| 202248_at | Serous | 1,207 | 0.92 | 0.78–1.07 | 0.28 | 1,104 | 1.20 | 1.03–1.4 | 0.02 | 735 | 1.21 | 1.01–1.45 | 0.04 |
| Endometrioid | 37 | — | — | — | 51 | 2.01 | 0.75–5.36 | 0.15 | 14 | — | — | — | |
| E2F5 | Overall | 1,656 | 1.10 | 0.96–1.25 | 0.16 | 1,435 | 1.25 | 1.08–1.44 | 0.00 | 782 | 0.85 | 0.7–1.02 | 0.08 |
| 221586_s_at | Serous | 1,207 | 0.92 | 0.79–1.08 | 0.31 | 1,104 | 0.95 | 0.82–1.09 | 0.45 | 735 | 0.86 | 0.71–1.05 | 0.14 |
| Endometrioid | 37 | 0.33 | 0.06–1.99 | 0.20 | 51 | 0.32 | 0.12–0.81 | 0.01 | 14 | — | — | — | |
| E2F6 | Overall | 1,656 | 1.12 | 0.96–1.3 | 0.14 | 1,435 | 1.20 | 1.06–1.36 | 0.00 | 782 | 0.85 | 0.71–1.01 | 0.06 |
| 203957_at | Serous | 1,207 | 0.90 | 0.77–1.06 | 0.21 | 1,104 | 1.06 | 0.92–1.23 | 0.43 | 735 | 0.82 | 0.69–0.98 | 0.03 |
| Endometrioid | 37 | 6.63 | 0.74–59.46 | 0.05 | 51 | 1.44 | 0.55–3.78 | 0.46 | 14 | — | — | — | |
| E2F7 | Overall | 655 | 1.28 | 1.02–1.6 | 0.03 | 614 | 1.12 | 0.93–1.35 | 0.24 | 382 | 1.36 | 1.06–1.75 | 0.02 |
| 228033_at | Serous | 523 | 1.31 | 1.04–1.64 | 0.02 | 483 | 0.88 | 0.7–1.11 | 0.27 | 346 | 1.35 | 1.04–1.76 | 0.03 |
| Endometrioid | 30 | — | — | 0.13 | 51 | 0.41 | 0.14–1.19 | 0.09 | 10 | — | — | — | |
| E2F8 | Overall | 1,435 | 1.19 | 1.04–1.61 | 0.02 | 1,435 | 1.25 | 1.08—1.44 | 0.00 | 782 | 1.15 | 0.96–1.38 | 0.12 |
| 219990_at | Serous | 1,207 | 1.24 | 1.04–1.48 | 0.02 | 1,104 | 0.88 | 0.76–1.01 | 0.07 | 735 | 1.18 | 0.98–1.42 | 0.09 |
| Endometrioid | 37 | — | — | — | 51 | 2.82 | 1.00–7.96 | 0.04 | 14 | — | — | — | |
The bold values indicate that the results are statistically significant.