Table 2.
Characteristics of study population.
| Group A (n = 62) |
Group B (n = 34) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Cow's milk |
Hen's egg |
Cow's milk |
Hen's egg |
|||||
| Median/n | IQR/% | Median/n | IQR/% | Median/n | IQR/% | Median/n | IQR/% | |
| Patients (n,%) | 35 | 56 | 27 | 44 | 20 | 59 | 14 | 41 |
| Male (n,%) | 18 | 29 | 15 | 24 | 11 | 32 | 6 | 18 |
| Age (y) (mean ± SD) | 8.9 ± 2.3 | 7.3 ± 2.6 | 7.9 ± 2 | 7.7 ± 2 | ||||
| Caucasian (n, %) | 35 | 56 | 27 | 44 | 20 | 59 | 14 | 41 |
| Other allergic comorbidities | ||||||||
| Additional food allergies (n, %)a | 3 | 5 | 6 | 10 | 1 | 3 | 3 | 9 |
| Allergic asthma (n, %) | 11 | 18 | 7 | 11 | 6 | 18 | 4 | 12 |
| Allergic rhinitis (n, %) | 10 | 16 | 11 | 18 | 7 | 21 | 5 | 15 |
| Atopic dermatitis (n, %) | 7 | 11 | 4 | 6 | 3 | 9 | 2 | 6 |
| Food specific data | ||||||||
| Baseline IgE (kU/L), median (range)b | 32.5 | (8.2-126) | 36.5 | (5-110) | 25.8 | (5.5-98) | 38.5 | (4.3-98.6) |
| Baseline SPT wheal diameter (mm), median (range)b | 7 | (5-15) | 11 | (7-20) | 7 | (5-16) | 9 | (6-17) |
| Baseline OFC successfully consumed dose (mg), median (IQR)b | 13.2 | (0-105.6) | 0.8 | (0-100) | 6.6 | (0-105.6) | 1.5 | (0-100) |
| Clinical presentation (baseline OFC) | ||||||||
| Anaphylactic shock (n, %) | 8 | 13 | 9 | 15 | 4 | 12 | 5 | 15 |
| Asthma (n, %) | 9 | 15 | 6 | 10 | 5 | 15 | 4 | 12 |
| Diarrhea (n,%) | 4 | 6 | 4 | 6 | 2 | 6 | 3 | 9 |
| Rhinitis (n, %) | 17 | 27 | 11 | 18 | 10 | 29 | 7 | 21 |
| Urticaria (n, %) | 15 | 24 | 19 | 31 | 9 | 26 | 10 | 29 |
| Vomiting (n,%) | 10 | 16 | 13 | 21 | 5 | 15 | 5 | 15 |
| AR(s) during maintenance phase | ||||||||
| Mild-moderate ARs (n, %) | 4 | 6 | 0 | 0 | 1 | 3 | 0 | 0 |
| Mild-moderate ARs per patient, median (IQR) | 3 | (2.25-4.5) | 0 | (0-0) | 0 | (0-0) | 0 | (0-0) |
| Severe ARs (n, %) | 5 | 8 | 3 | 5 | 0 | 0 | 0 | 0 |
| Severe ARs per patient, median (IQR) | 2 | (1-2.5) | 3 | (2-5) | 0 | (0-0) | 0 | (0-0) |
| Eosinophilic Esophagitis (n,%) | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Total Patients with ARs (n, %)c | 10 | 16 | 3 | 5 | 1 | 2 | 0 | 0 |
Data were summarized as numbers (n) and frequencies (%) if they were categorical and as mean/median and SD/IQR if quantitative.
All characteristics were not statistically significantly different between groups and subgroups.
AR, Food-related adverse reaction; IQR, Interquartile range; OFC, oral food challenge; SPT, skin prick test.
a
Includes egg (when different from OIT food), milk (when different from OIT food), tree nuts, fish, and wheat.
b
Values referred to cow's milk or hen's egg according to the respective group.
c
P values were statistically significant for comparisons between total patients with ARs (group A vs group B, p = .002); cow's milk and hen's egg subgroups were combined for the analysis.