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. 2019 Mar 22;10:550. doi: 10.3389/fimmu.2019.00550

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Copyright © 2019 Adi, Eiza, Bejar, Shefer, Toledano, Kessler, Neufeld, Toubi and Vadasz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sema3A inhibits the infiltration of inflammatory cells into the lungs of OVA sensitized asthmatic mice. (A) Infiltration of inflammatory cells around bronchiole, in sema3A treated mice. Black arrow denotes inflammation (Magnification X20). (B) Infiltration of inflammatory cells around bronchioles and blood vessel, in vehicle treated mice. Black arrows denote massive inflammation (Magnification X20). (C) Percentage of bronchioles and blood vessels that are surrounded by inflammatory cells in HPF. The results are the mean value of 3–5 HPF, derived from 15 mice in each group.