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. 2019 Mar 22;10:550. doi: 10.3389/fimmu.2019.00550

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Copyright © 2019 Adi, Eiza, Bejar, Shefer, Toledano, Kessler, Neufeld, Toubi and Vadasz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of sema3A on angiogenesis induced by OVA sensitization in lungs of mice. (A) Blood vessels in the lung tissue in vehicle treated mice were stained with an antibody directed against CD31 as described in materials and methods. Shown is a representative HPF. Black arrows denote microvessels. (B) Shown is a representative HPF. Blood vessels in the lung tissue in sema3A treated mice were stained similarly. Almost no blood vessels can be seen. (C) Quantification of the blood vessels concentration across all examined histological slides in vehicle treated and in sema3A treated mice (15 mice in each group, P = 0.0013).