Table 2. Adjusted Competing Risk Regression Model for Factors Associated With Local Recurrence of Previously Treated Brain Metastases^a.

Variable	HR (95% CI)	P Value
Surgical resection vs SRSb	1.15 (0.72-1.83)	.56
Time of recurrence, moc
0-3	5.94 (1.72-20.45)	.005
3-6	1.37 (0.64-2.90)	.47
6-9	0.75 (0.28-2.00)	.56
≥9	0.36 (0.14-0.93)	.04
Diameter of lesion	1.03 (1.00-1.06)	.03
Baseline neurologic status
No neurologic deficit	1 [Reference]	NA
Some deficit, useful work	1.31 (0.83-2.06)	.25
Moderate impairment	0.98 (0.53-1.79)	.94
Metastasis site
Temporal	1 [Reference]	NA
Frontal	1.40 (0.71-2.76)	.33
Occipital	1.60 (0.76-3.40)	.22
Parietal	1.01 (0.48-2.12)	.98
Posterior fossa	0.95 (0.43-2.11)	.89
Other	0.24 (0.03-2.04)	.19
Macroscopic tumor outside brain
Absent	1 [Reference]	NA
Present	0.63 (0.40-0.99)	.04
No. of brain metastases
1	1 [Reference]	NA
2	0.78 (0.38-1.59)	.49

Abbreviations: HR, hazard ratio; NA, not applicable; SRS, stereotactic radiosurgery.

^aModel is stratified according to receipt of whole-brain radiotherapy.

^bRepresents overall hazard of surgical resection vs SRS.

^cEvaluates surgical resection vs SRS according to period.