Table 1. Baseline Characteristics of Study Participants by Treatment Group.
| Characteristics | Acetaminophen-Dexmedetomidine (n = 29) | Placebo-Dexmedetomidine (n = 30) | Acetaminophen-Propofol (n = 31) | Placebo-Propofol (n = 30) |
|---|---|---|---|---|
| Demographics | ||||
| Sex, No. (%) | ||||
| Male | 26 (89.7) | 25 (83.3) | 24 (77.4) | 26 (86.7) |
| Female | 3 (10.3) | 5 (16.7) | 7 (22.6) | 4 (13.3) |
| Age, median (IQR), y | 64 (63-72) | 69 (63-74) | 70 (66-75) | 71 (64-79) |
| Patient-reported race, No. (%)a | ||||
| White | 26 (89.7) | 28 (93.3) | 29 (93.6) | 28 (93.3) |
| Black/African American | 2 (6.9) | 1 (3.3) | 1 (3.2) | 1 (3.3) |
| Asian | 0 | 0 | 1 (3.2) | 0 |
| Multiracial | 0 | 0 | 0 | 1 (3.3) |
| Other | 0 | 1 (3.3) | 0 | 0 |
| Unknown/not specified | 1 (3.5) | 0 | 0 | 0 |
| Hispanic or Latino, No. (%) | 1 (3.5) | 1 (3.3) | 0 | 2 (6.7) |
| Weight, median (IQR), kg | 89.1 (80.4-102.0) |
87.6 (82.0-102.0) |
84.1 (79.0-93.2) |
90.0 (75.8-107.0) |
| Height, median (IQR), cm | 173.0 (167.6-180.3) |
172.7 (167.6-178.0) |
170.2 (167.6-173.3) |
175.1 (167.6-180.0) |
| Body mass index, median (IQR)b | 29.7 (26.6-32.3) |
29.4 (27.0-32.0) |
28.5 (26.6-32.3) |
29.2 (25.9-34.3) |
| Surgical characteristics | ||||
| Procedure, No. (%) | ||||
| Isolated CABG surgery | 19 (65.5) | 18 (60.0) | 19 (61.3) | 23 (76.7) |
| CABG surgery + mitral valve replacement | 1 (3.5) | 0 | 1 (3.2) | 0 |
| CABG surgery + aortic valve replacement | 8 (27.6) | 8 (26.7) | 10 (32.3) | 6 (20.0) |
| Otherc | 1 (3.5) | 4 (13.3) | 1 (3.2) | 1 (3.3) |
| No. of arteries affected, median (IQR) | 3 (2-4) | 3 (2-3) | 3 (2-3) | 3 (2-3) |
| Preoperative statin use, No. (%) | 24 (82.8) | 25 (83.3) | 29 (93.6) | 27 (90.0) |
| Cross-clamp time, median (IQR), min | 67 (58-84) | 73 (60-93) | 78 (66-87) | 64 (54-96) |
Abbreviations: CABG, coronary artery bypass graft; IQR, interquartile range.
a
Race was documented using patient-reported values from predetermined fixed categories.
b
Calculated as weight in kilograms divided by height in meters squared.
c
Other includes CABG surgery plus maze procedure, CABG surgery plus ascending aorta replacement, and CABG surgery plus pulmonary vein isolation with or without valve replacement.