Table 2. Demographic and Clinical Characteristics of the PheWAS Analytic Data Set by Tertile of International Thyrotropin Polygenic Risk Score.
| Variable | No. (%) | ||
|---|---|---|---|
| Lowest GRS Tertile | Middle GRS Tertile | Highest GRS Tertile | |
| No. | 12 378 | 12 409 | 12 366 |
| Male, No. (%) | 6399 (51.7) | 6444 (51.9) | 6487 (52.5) |
| Birth, median (IQR), y | 1945 (1935-1955) | 1945 (1935-1955) | 1945 (1935-1955) |
| Patients with at least 1 phecodea,b | |||
| Atrial fibrillation and/or flutter (phecode 427.2) | 2712 (33.9) | 2580 (32.3) | 2500 (31.5) |
| Nonhypertensive congestive heart failure (phecode 428) | 2832 (26.6) | 2775 (26.1) | 2702 (25.5) |
| Hypertension (phecode 401) | 8725 (70.5) | 8773 (70.7) | 8639 (69.9) |
| Ischemic heart disease (phecode 411) | 4887 (41.4) | 4914 (41.4) | 4954 (41.9) |
| Ventricular tachycardia (phecode (427.12) | 805 (12.9) | 758 (12.0) | 680 (10.8) |
| Diabetes (phecode 250) | 4205 (38.7) | 4067 (37.3) | 4064 (37.5) |
| Hypothyroidism (phecode 244) | 2264 (19.7) | 2461 (21.1) | 2613 (22.5) |
| Thyrotoxicosis with/without goiter (phecode 242) | 516 (5.3) | 452 (4.7) | 424 (4.5) |
| Nontoxic nodular thyroid goiter (phecode 241) | 784 (7.8) | 690 (7.0) | 515 (5.4) |
Abbreviations: GRS, polygenic risk score; IQR, for interquartile range; PheWAS, phenome-wide association study.
a
Percentages of individuals with a diagnosis are based on the counts of cases and controls, and counts will differ for each phenotype.
b
PheWAS uses International Classification of Diseases codes to define a set of computable phenotypes or phecodes defined and validated by experts using a combination of International Classification of Diseases codes.8