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. 2019 Jan 7;179(2). doi: 10.1001/jamainternmed.2018.6112

Figure 1. Changes Over Time in Main Associated Diagnoses Among Study Patients in the Optum Database.

Figure 1.

Includes patients with amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), or dementia and/or Parkinson disease (PD) who received a prescription for dextromethorphan hydrobromide and quinidine sulfate from 2011 through 2017. The diagnoses were identified before and within 30 days after a prescription claim for the combination drug dextromethorphan-quinidine in the Optum Clinformatics Data Mart database. The exact periods represented by each year were October 29, 2010, through September 30, 2011 (2011); October 1, 2011, through September 30, 2012 (2012); October 1, 2012, through September 30, 2013 (2013); October 1, 2013, through September 30, 2014 (2014); October 1, 2014, through September 30, 2015 (2015); October 1, 2015, through September 30, 2016 (2016); and October 1, 2016, through March 1, 2017 (2017).