Figure 2. Association Between Mutated Genes and Incidence of Death Combined With Rehospitalization for Heart Failure and Kaplan-Meier Event-Free Survival Curves in Patients With Chronic Heart Failure (CHF).

A, Bubble size reflects the sample size of patients carrying each individual mutation, dashed line reflects incidence of death combined with rehospitalization for heart failure for patients who were not carriers of clonal hematopoiesis of indeterminate potential (CHIP). See eTable 1 in the Supplement for gene annotation. B, Overall survival of patients with DNMT3A or TET2 mutations with a variant allele fraction (VAF) of at least 0.02 vs non-CHIP patients. C, Event-free survival free of death or rehospitalization for heart failure with DNMT3A or TET2 mutations with a VAF of at least 0.02 vs non-CHIP patients. P values are for log-rank tests.