Table 3. Candidate Genes Associated With Early-Onset Breast or Ovarian Cancera.
| Gene | Cases, Mutated Alleles, No. (Total No. of Alleles) |
Controls, Mutated Alleles, No.
(Total No. of Alleles) |
OR (95% CI)b | P Value |
|---|---|---|---|---|
| Breast cancer | ||||
| ATMc | 34 (4804) | 14 (6038) | 3.07 (1.60-6.19) | 2.26 × 10−4 |
| CHEK2c | 57 (5630) | 24 (6442) | 2.73 (1.67-4.61) | 1.69 × 10−5 |
| MSH6 | 29 (7601) | 11 (7806) | 2.71 (1.31-6.03) | 3.90 × 10−3 |
| PALB2c | 24 (6812) | 5 (7314) | 5.17 (1.93-17.35) | 2.40 × 10−4 |
| Ovarian cancer | ||||
| ATM | 1 (492) | 14 (6095) | 0.88 (0.02-5.84) | >.99 |
| MSH6c | 8 (852) | 11 (7826) | 6.73 (2.34-18.43) | 2.35 × 10−4 |
| RAD51Cc | 1 (344) | 0 (4804) | ND | .07 |
| TP53c | 3 (749) | 1 (7209) | 28.96 (2.32-1506.64) | 3.09 × 10−3 |
Abbreviation: ND, not determined.
a
Diagnosis age 45 years or younger.
b
Derived from Fisher exact test.
c
Known breast or ovarian cancer gene.