Figure 3. Fibrotic Nodules With Intraretinal Rosettes in Coats Disease.

A, OCT from a 4-year-old boy. Low-power (B) and high-power (C and D) light micrographs from an enucleated biorepository eye. A hyperreflective tubule with a hyporeflective core (green arrowhead) overlying exudates (yellow arrowheads) and a fibrotic nodule (red arrows) with subretinal fluid (blue arrowhead) is observed on OCT. This tubule appears to correspond to the intraretinal rosettes (green arrowheads) in the disorganized retina overlying the cholesterol granuloma on the high-power light micrograph (C). Other notable findings on light micrograph include a fibrous capsule surrounding the cholesterol granuloma (black arrowheads) as well as multinucleated giant cells with pigment granules (white arrowheads) surrounding cholesterol clefts (yellow arrowheads), proliferating capillaries (orange arrowheads), and fibrinous material (red arrowheads) within the cholesterol granuloma. The horizontal white dotted line in the inset photograph corresponds with the OCT line scan while the black dotted boxes on the low-power micrograph denote the areas above and within the cholesterol granuloma shown in the high-power micrographs