Figure 2. Association of Extensive White Matter Hyperintensity (WMH) Burden With Incident Stroke, Dementia, and Death.

The association of extensive WMH of presumed vascular origin with incident stroke (A) (overall: I² = 56%; P = .003; in the general population [GP]: I² = 0%; P = .43; in high-risk populations [HRP]: I² = 67%; P < .001), incident dementia (B) (overall: I² = 64%; P = .001; GP: I² = 79%; P = .003; HRP: I² = 53%; P = .04), and mortality (C) (overall: I² = 41%; P = .06). Results correspond to hazard ratios (HRs) with 95% CIs for each study; the meta-analysis results (inverse variance–weighted meta-analysis with random effects) are shown in diamonds. The No./total No. corresponds to the number of individuals with the outcome of interest and the total sample size.