Table 2. Distribution of Standard Antigen, Broad Specificity, and Cross-Reactive Group Mismatchesa.
| HLA Antigen Mismatch Level | Frequency, No. (%) | ||
|---|---|---|---|
| Standard Antigen Mismatch Method (n = 7285) | Broad Specificity Mismatch Method (n = 7285) | CREG Mismatch Method (n = 7745) | |
| HLA-A | |||
| 0 | 805 (9.9) | 1013 (12.6) | 3300 (40.9) |
| 1 | 3398 (42.2) | 3849 (47.7) | 3576 (44.4) |
| 2 | 3859 (47.9) | 3200 (39.7) | 1057 (13.1) |
| 3 | NA | NA | 129 (1.6) |
| HLA-B | |||
| 0 | 689 (8.2) | 734 (8.7) | 2151 (25.5) |
| 1 | 2504 (29.7) | 2753 (32.6) | 3058 (36.2) |
| 2 | 5241 (64.1) | 4947 (58.7) | 2401 (28.5) |
| 3 | NA | NA | 743 (8.8) |
| 4 | NA | NA | 80 (1.0) |
| 5 | NA | NA | 1 (0.01) |
| HLA-DR | |||
| 0 | 900 (11.1) | 1080 (13.3) | NA |
| 1 | 3391 (41.7) | 3672 (45.2) | NA |
| 2 | 3837 (47.2) | 3376 (41.5) | NA |
| Combined HLA | |||
| 0 | 306 (4.2) | 344 (4.7) | 1100 (14.2) |
| 1 | 194 (2.7) | 203 (2.8) | 1656 (21.4) |
| 2 | 379 (5.2) | 455 (6.3) | 2284 (29.5) |
| 3 | 1038 (14.2) | 1234 (16.9) | 1774 (22.9) |
| 4 | 1337 (18.4) | 1604 (22.0) | 733 (9.5) |
| 5 | 2335 (32.0) | 2250 (39.9) | 169 (2.2) |
| 6 | 1696 (23.3) | 1195 (16.4) | 27 (0.3) |
| 7 | NA | NA | 2 (0.03) |
| 8 | NA | NA | 0 |
Abbreviations: CREG, cross-reactive group; NA, not applicable.
a
Standard and broad specificity mismatch levels range from 0 to 2 for HLA-A, HLA-B, and HLA-DR, for a combined range of 0 to 6. The CREG mismatch levels range from 0 to 3 for HLA-A and 0 to 5 for HLA-B, for a combined range of 0 to 8.