Table 2.

Structural MRI data from depressed and non-depressed patients with MS and healthy controls.

	DMS (n = 22)	nDMS (n = 21)	HCs (n = 12)	DMS vs nDMS			DMS vs HCs			nDMS vs HCs
				Difference (CI)	p value	p corr.	Difference (CI)	p value	p corr.	Difference (CI)	p value	p corr.
NWMV (mL)	667.68 (34.89)	706.98 (47.90)	739.46 (31.59)	−38.08 (−63.21 to −12.95)	<0.01	<0.01	−68.53 (−99.02 to −38.03)	<0.001	<0.001	−30.45 (−60.00 to −0.90)	0.04	0.07
NGMV (mL)	745.76 (56.61)	715.45 (50.63)	767.45 (37.74)	13.75 (−8.81 to 36.31)	0.23	0.31	−42.56 (69.94 to −15.18)	<0.01	<0.01	−56.30 (−82.84 to −29.77)	<0.001	<0.01
T2LL (mL)	5.69 (5.92)	7.45 (5.43)	–	−1.57 (−5.07 to 1.92)	0.37	0.46	–	–	–	–	–	–
Hippocampus L (mL)	4.74 (0.68)	4.66 (0.69)	5.60 (0.61)	−0.01 (−0.41 to 0.40)	0.97	0.97	−0.96 (−1.45 to −0.47)	<0.001	<0.01	−0.96(−1.43 to −0.48)	<0.001	<0.01
Hippocampus R (mL)	4.80 (0.76)	4.51 (0.73)	5.36 (0.86)	0.19 (−0.28 to 0.65)	0.42	0.48	−0.67 (−1.24 to −0.11)	0.02	0.03	−0.86 (−1.40 to −0.31)	<0.01	<0.01
Amygdala L (mL)	1.55 (0.36)	1.59 (0.32)	1.82 (0.24)	−0.08 (−0.28 to 0.11)	0.40	0.47	−0.31 (−0.54 to −0.07)	0.01	0.02	−0.22 (−0.45 to 0.00)	0.06	0.08
Amygdala R (mL)	1.62 (0.41)	1.50 (0.29)	1.96 (0.27)	0.10 (−0.10 to 0.30)	0.32	0.42	−0.31 (−0.55 to −0.07)	0.01	0.02	−0.41 (−0.65 to −0.18)	<0.01	<0.01
Thalamus L (mL)	9.61 (1.00)	9.39 (1.39)	10.82 (0.85)	0.03 (−0.60 to 0.67)	0.91	0.95	−1.35 (−2.12 to −0.58)	<0.001	<0.01	−1.39 (−2.13 to −0.64)	<0.001	<0.01
Thalamus R (mL)	9.33 (1.05)	9.06 (1.20)	10.35 (0.58)	0.07 (−0.50 to 0.64)	0.80	0.86	−1.21 (−1.90 to −0.51)	<0.001	<0.01	−1.28 (−1.95 to −0.61)	<0.001	<0.01

CI: confidence interval; corr.: FDR-corrected p value; DMS: depressed multiple sclerosis patients; HCs: healthy controls; L: left; MS: multiple sclerosis; MRI: magnetic resonance imaging; NGMV: normalized gray matter volume; nDMS: non-depressed multiple sclerosis patients; NWMV: normalized white matter volume; R: right; T2LL: T2-weighted lesion load.

Displayed data are mean (standard deviation) values.