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. 2019 Feb 27;54(5):1691–1703. doi: 10.3892/ijo.2019.4733

Figure 5.

Figure 5

ZNF692 knockdown inhibits xenograft tumor growth in nude mice. (A) ZNF692 knockdown reduced DLD-1 cell-derived xenograft tumor growth in nude mice (n=5). (B) Statistical comparison of differences in tumor weights and (C) volumes between the sh-NC and sh-ZNF692 #1 groups. (D) Growth curve of DLD-1 xenograft tumors monitored in the sh-NC and sh-ZNF692 #1 groups. (E) Expression levels and nuclear localization of ZNF692 protein were determined using immunofluorescence in xenograft tumor tissues in the sh-NC and sh-ZNF692 #1 groups. Magnification, ×400. Scale bar, 50 µm. (F) HE staining (magnification, ×200; scale bar, 100 µm) and immunohistochemistry analysis of Ki-67 expression (magnification, ×400; scale bar, 50 µm) in xenograft tumor tissues in the sh-NC and sh-ZNF692 #1 groups. The data are presented as the mean ± standard deviation. *P<0.05 and **P<0.01 vs sh-NC. ZNF692, zinc finger protein 692; sh, short hairpin; NC, negative control; HE, hematoxylin and eosin.