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. 2019 Mar 19;54(5):1651–1664. doi: 10.3892/ijo.2019.4758

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Copyright: © Gao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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CASC9 expression heat-map, gene alteration prediction and correlation analysis. (A) Heat-map of CASC9 expression in 191 lung cancer cell lines arranged from high to low, corresponding to the spectrum of colors from red to green. (B) A total of 4 (2.2%) incidences of CASC9 amplification were revealed in 179 sequenced cases. (C) Correlation between the expression of CASC9 and predicted transcription factors or adjacent protein-coding genes. CASC9 was positively correlated with FOSL2 (r=0.126; P=0.0046), CRISPLD1 (r=0.269; P<0.001) and HNF4G (r=0.196; P<0.001), and negatively correlated with EBF1 (r=−0.129; P=0.0038). CASC9, cancer susceptibility candidate 9; GISTIC, genomic identification of significant targets in cancer; FOSL2, Fos-related antigen 2; EBF1, transcription factor COE1; CRISPLD1, cysteine-rich secretory protein LCCL domain-containing 1; HNF4G, hepatocyte nuclear factor 4-γ.