Table 2.

Meta-analysis of the association between rs2569190 (C-260T) polymorphism and CVD risk

Sub-group analysis	No of data sets	No of cases/controls		Allele model (T VS.C)		Dominant model (CC VS.TT + CT)				Recessive model (TT VS.CC + CT)
		Cases	Controls	OR (95% CI)	POR	PH	OR (95% CI)	POR	PH	OR (95% CI)	POR	PH
Overall	24	9413	7337	1.169(1.087–1.257)	2.44 × 10−5*	0.001	1.233(1.110–1.370)	3.79 × 10−5*	0.02	1.195(1.062–1.345)	0.003*	0.002
Ethnicity
East Asian	7	1503	1597	1.370(1.226–1.531)	2.86 × 10−8*	0.308	1.574(1.278–1.938)	9.11 × 10−7*	0.217	1.492(1.236–1.801)	3.05 × 10−5*	0.22
European	16	7403	5353	1.100(1.019–1.189)	0.015	0.047	1.113(1.006–1.232)	0.039	0.237	1.112(0.975–1.269)	0.113	0.04
America	1	387	387	1.000(0.819–1.221)	1	–	1.142(0.830–1.571)	0.416	–	0.827(0.584–1.173)	0.287	–
Endpoint
CHD	7	1019	1005	1.357(1.157–1.592)	2.47 × 10−7*	0.074	1.669(1.388–2.007)	2.48 × 10−6*	0.433	1.342(1.011–1.781)	0.042	0.035
AMI	7	762	1244	1.152(1.036–1.281)	0.009	0.143	1.186(0.997–1.412)	0.054	0.131	1.162(1.030–1.310)	0.015	0.483
MI	10	4641	3915	1.077(0.976–1.188)	0.139	0.072	1.061(0.949–1.186)	0.297	0.799	1.118(0.907–1.378)	0.297	0.002

OR odd ratio, 95%CI 95% confidence interval, P_ORP value for the test of association, P_HP value for heterogeneity analysis

^∗Significant P-value