Table 3.

Meta-analysis of the association between C-159T polymorphism and CVD risk

Sub-group analysis	No of data sets	No of cases/controls		Allele model (T VS.C)			Dominant model (CC VS.TT + CT)			Recessive model (TT VS.CC + CT)
		Cases	Controls	OR (b95% CI)	POR	PH	OR (95% CI)	POR	PH	OR (95% CI)	POR	PH
Overall	13	4813	2852	1.009(0.941–1.082)	0.854	0.078	1.049(0.936–1.176)	0.41	0.164	1.009(0.900–1.132)	0.878	0.324
Ethnicity
East Asian	6	834	886	0.881(0.723–1.075)	0.212	0.066	1.120(0.888–1.413)	0.34	0.109	1.198(0.974–1.474)	0.087	0.327
European	6	3769	1734	1.039(0.953–1.132)	0.387	0.717	0.923(0.806–1.058)	0.249	0.488	0.962(0.832–1.113)	0.602	0.751
Indian	1	210	232	1.249(0.958–1.628)	0.101	–	0.718(0.445–1.160)	0.176	–	0.734(0.479–1.125)	0.156	–
Endpoint
EH-LVH	2	219	216	0.974(0.746–1.271)	0.845	0.81	1.045(0.669–1.631)	0.847	0.817	1.028(0.672–1.573)	0.898	0.87
EH-NLVH	2	207	216	0.846(0.646–1.109)	0.227	0.981	1.051(0.669–1.653)	0.828	0.967	1.424(0.938–2.162)	0.097	0.957
CHD	3	459	503	0.804(0.514–1.257)	0.338	0.007	1.292(0.953–1.785)	0.121	0.007	1.186(0.904–1.556)	0.217	0.1
AMI	4	2989	1325	1.048(0.950–1.156)	0.351	0.512	0.926(0.790–1.085)	0.342	0.729	0.917(0.778–1.080)	0.3	0.314
MI	2	939	592	1.109(0.952–1.293)	0.184	0.664	0.817(0.642–1.038)	0.098	0.669	0.957(0.735–1.246)	0.743	0.851

OR odd ratio, 95%CI 95% confidence interval, P_ORP value for the test of association, P_HP value for heterogeneity analysis