Fig. 3.

Effect of exogenous heparan sulfate on the expression of both heparanases. The values represent the median and range of the protein expression performed in triplicate assays using lymphocytes obtained from three different healthy donors or three patients with breast cancer. a Lymphocytes control, circulating T-lymphocytes collected from healthy woman (woman not affected by cancer; b Lymphocytes patient, circulating T-lymphocytes obtained from breast cancer patient; +HS, T-lymphocytes incubated with 50 μg/mL of heparan sulfate (HS), during 4 h at 37 °C. Kruskal–Wallis test with Dunn auxiliary test, *p < 0.0001