Table 1.
Comparison between AD patients (A+T+N+ classification) who were included and not included in the analyses due to missing data
| Characteristics | AD patients with A+T+N+ profile | ||
|---|---|---|---|
| Included | Not included | ||
| (N = 321) | (N = 61) | P value | |
| Age, year, mean (SD) | 71.0 (8.5) | 71.3 (8.1) | 0.68 |
| Women, n (%) | 200 (62.3) | 37 (59.7) | 0.70 |
| MMSE, mean (SD) | 20.3 (5.8) | 20.3 (6.7) | 0.85 |
| Level of education, n (%)a | |||
| Low | 106 (35.8) | 15 (31.9) | |
| Intermediate | 110 (36.8) | 11 (23.4) | |
| High | 81 (27.4) | 21 (44.7) | 0.04 |
| CSF biomarkers, pg/mL, mean (SD) | |||
| Aβ42 | 483.8 (134.8) | 471.8 (133.7) | 0.52 |
| Aβ40b | 13,345 (5447) | 13,323 (4812) | 0.92 |
| Ratio Aβ42/40b | 0.047 (0.022) | 0.044 (0.017) | 0.57 |
| Tau | 684.9 (276.9) | 671.8 (285.9) | 0.72 |
| p-Tau 181 | 102.6 (39.0) | 100.9 (39.5) | 0.73 |
A+T+N+ profile: Abnormal values for three CSF biomarkers (Aβ42, total tau, phosphorylated tau (p-tau 181))
AD Alzheimer’s disease, SD standard deviation
aLow: primary school or less, intermediate: secondary to high school, high: baccalaureate or university degree
bCSF Aβ40 was available for 255 patients