Table 3.
Characteristics associated with death and institutionalization during the follow-up
| Characteristics | Death | Institutionalization | ||||
|---|---|---|---|---|---|---|
| No | Yes | No | Yes | |||
| (N = 264) | (N = 57) | P value | (N = 250) | (N = 71) | P value | |
| Age, year, mean (SD) | 70.4 (8.2) | 73.8 (9.3) | 0.001 | 71.0 (8.2) | 70.9 (9.5) | 0.89 |
| Women, n (%) | 172 (65.2) | 28 (49.1) | 0.02 | 159 (63.6) | 41 (57.8) | 0.39 |
| MMSE, mean (SD) | 20.7 (5.6) | 18.3 (6.6) | 0.008 | 20.7 (5.9) | 18.9 (5.5) | 0.01 |
| Level of education, n (%) | ||||||
| Low | 82 (33.7) | 24 (44.4) | 86 (37.7) | 20 (29.0) | ||
| Intermediate | 92 (37.9) | 18 (33.3) | 77 (33.8) | 33 (47.8) | ||
| High | 69 (28.4) | 12 (22.2) | 0.32 | 65 (28.5) | 16 (23.2) | 0.10 |
| APOE ε4, n (%) | ||||||
| 0 | 100 (37.9) | 25 (43.9) | 99 (39.6) | 26 (36.6) | ||
| 1 | 117 (44.3) | 24 (42.1) | 106 (42.4) | 35 (49.3) | ||
| 2 | 47 (17.8) | 8 (14.0) | 0.65 | 45 (18.0) | 10 (14.1) | 0.54 |
| CSF biomarkers, pg/mL, mean (SD) | ||||||
| Aβ42 | 505.9 (127.8) | 381.6 (118.7) | < 0.001 | 496.6 (135.9) | 438.7 (121.3) | 0.001 |
| Aβ40b | 13,284 (5362) | 13,474 (6697) | 0.51 | 13,195 (5351) | 14,165 (6312) | 0.36 |
| Ratio Aβ42/40b | 0.047 (0.022) | 0.039 (0.013) | 0.08 | 0.046 (0.019) | 0.049 (0.038) | 0.56 |
| Tau | 680.9 (273.0) | 703.6 (296.2) | 0.69 | 685.4 (280.0) | 683.2 (267.5) | 0.93 |
| p-Tau 181 | 102.5 (41.0) | 102.9 (28.3) | 0.88 | 102.5 (39.5) | 102.8 (37.4) | 0.94 |
aLow: primary school or less, intermediate: secondary to high school, high: baccalaureate or university degree
bCSF Aβ40 was available for 214 patients