Table 4.

Predictors of death and institution over the follow-up, multivariable Cox regression analyses

Characteristics	Death		Institutionalization
	HR (95% CI)	P value	HR (95% CI)	P value
Age, yeara	1.66 (1.21–2.28)	0.002	1.11 (0.86–1.44)	0.44
Men vs women	2.11 (1.19–3.76)	0.01	1.56 (0.94–2.59)	0.09
Level of educationb
Low	Ref.	–	Ref.	–
Intermediate	1.21 (0.58–2.52)	0.61	2.45 (1.25–4.83)	0.009
High	1.02 (0.45–2.31)	0.96	1.45 (0.68–3.09)	0.33
MMSE scorec	1.56 (1.16–2.10)	0.003	1.68 (1.29–2.18)	< 0.001
APOE ε4 allele
0	Ref.	–	Ref.	–
1	0.79 (0.43–1.44)	0.44	1.00 (0.58–1.73)	0.98
2	0.59 (0.25–1.36)	0.21	0.70 (0.32–1.52)	0.37
Collection tube, before 2012 vs recent	1.37 (0.60–3.01)	0.46	0.74 (0.36–1.52)	0.41
CSF Aβ42, pg/mLc	1.89 (1.25–2.86)	0.002	0.89 (0.60–1.32)	0.55
CSF tau, pg/mLa	1.11 (0.84–1.48)	0.45	0.99 (0.78–1.26)	0.96

^aContinuous, estimate for 1 standard deviation increase

^bLow: primary school or less, intermediate: secondary to high school, high: baccalaureate or university degree

^cContinuous, estimate for 1 standard deviation decrease