Table 1.
Baseline characteristics
| Dialysis (n = 192) | Conservative (n = 89) | P value | |
|---|---|---|---|
| Demographics | |||
| Age, years, mean ± SD | 75 ± 7 | 82 ± 6 | < 0.01 |
| Gender (% male) | 128 (67%) | 50 (56%) | 0.07 |
| Clinical parameters | |||
| Cause of kidney failure (%) | 0.40 | ||
| Renal vascular | 96 (50%) | 45 (51%) | |
| Diabetes | 31 (16%) | 17 (19%) | |
| Nephritis | 12 (6%) | 5 (6%) | |
| Other | 54 (28%) | 25 (28%) | |
| Dialysis modality (% PD) | 44 (23%) | – | |
| Access: Central venous line (% of HD) | 73 (38%) | – | |
| BMI (kg/m2), mean (±SD) | 27 ± 5 | 26 ± 5 | 0.43 |
| Systolic blood pressure (mmHg)1 | 150 ± 22 | 151 ± 26 | 0.73 |
| Diastolic blood pressure (mmHg)1 | 75 ± 14 | 75 ± 13 | 0.74 |
| Smoking (former, now), n (%) | 148 (77%) | 62 (70%) | 0.19 |
| Severe comorbiditya | 79 (41%) | 39 (44%) | 0.69 |
| Frailtyb | 148 (77%) | 78 (88%) | 0.06 |
| Laboratory values c | |||
| Hemoglobin (mmol/L) | 6.4 ± 0.9 | 7.1 ± 0.9 | < 0.01 |
| Albumin (g/L) | 34 ± 6 | 37 ± 6 | < 0.01 |
| eGFR CKD-EPI in ml/min/1.73 m2 | 8.0 ± 2.9 | 11.5 ± 4.0 | < 0.01 |
| < 10 ml/min/1.73 m2 (%) | 152 (79%) | 35 (39%) | < 0.01 |
| ≥10 ml/min/1.73 m2 (%) | 40 (21%) | 54 (61%) | |
| Social setting | |||
| Living alone | 81 (42%) | 50 (56%) | 0.03 |
| Living in a nursing home facility | 10 (5%) | 7 (8%) | 0.36 |
| University | 40 (21%) | 16 (18%) | 0.50 |
| Polypharmacy | |||
| Mean no of drugs ± SD | 12 ± 5 | 10 ± 3 | < 0.01 |
Legend: SD standard deviateion, PD peritoneal dialysis, HD Hemodialysis, BMI body mass index,
eGFR estimated glomerular filtration rate, 1Measured before dialysis session in dialysis patients
a Measured with CIRS-G, severe comorbidity is ≥ 2x socre 3 or ≥ 1x score 4,
bMeasured with the geriatric assessment (see Supplemental material Table 2)
c Measured before the first dialysis session in dialysis patients