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. 2019 Mar 29;38:141. doi: 10.1186/s13046-019-1119-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Proposed model depicting the oncogenic effects of the miR-96-5p/PTEN alterated expression in HNSCC . As shown in the miRNAs-validated targets interaction networks, PTEN is a direct target shared by both miRNA signatures in the tumoral and peritumoral HNSCC tissues. In particular, the oncogenic miR-96-5p directly binds to PTEN 3’UTR then commences the signaling cascade and leads to down regulation of the expression level of PTEN therefore, cell migration and resistance to radiotherapy and chemotherapy increase