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. 2019 Mar 29;17:102. doi: 10.1186/s12967-019-1851-1

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Gene/microRNA signatures associated with PCDH17 expression. a Left: volcano plot showing gene expression differences between patients with low and high PCDH17 expression. Significantly down-regulated genes (blue points) and up-regulated genes (red points) in patients with low PCDH17 expression are indicated. Right: heatmap showing the gene expression signature associated with PCDH17 expression (FDR < 0.05, |log2 FC| > 1.5). Up-regulated and down-regulated genes mentioned in the text are labeled on the rows or in the boxes. b Heatmap showing the microRNA expression signature associated with PCDH17 expression (FDR < 0.05, |log2 FC| > 1.5). Up-regulated and down-regulated microRNAs mentioned in the text are indicated. c UCSC browser screenshot of the microRNAs located on the 14q32 region. Top shows schematic representation of chromosome 14, with the 14q32 locus indicated as a red rectangle. Bottom shows the relative positions of the 39 microRNAs that are positively associated with PCDH17 expression (left, the 14q32.2 microRNA cluster; right, the 14q32.31 microRNA cluster)