Table 2.
Expression and co-expression in different location and cell types of fibroblast and stromal markers analyzed in this study
| Markers | Expression of the marker | Subpopulations |
|---|---|---|
| CD31 | Blood vessels | Endothelial cells |
| αSMA | Cancer stroma Blood vessels |
CAFs, Smooth muscle cells Myofibroblasts in healthy colon |
| PDGFRβ | Cancer stroma Blood vessels |
CAFs, myofibroblasts, pericytes |
| FAP | Cancer stroma | CAFs |
| CD45 | Immune cells | Immune cells, hematopoietic stem cells |
| FSP1 | Fibroblasts | Quiescent fibroblasts, cancer cells |
| PDGFRβ αSMA | Around CD31+ endothelial cells | Pericytes, smooth muscle cells? |
| Cancer stroma | CAFs | |
| FAP αSMA | Cancer stroma | CAFs |
| PDGFRβ αSMA FAP | Cancer stroma | CAFs |
| CD45 FSP1 | Cancer stroma | Macrophages / monocytes / fibroblast precursors or quiescent fibroblasts (?) |