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. 2019 Mar 28;18:76. doi: 10.1186/s12944-019-1023-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Top 3 modules from the PPI network. The significant 3 clusters marked a, b and c, respectively, identified from the PPI network with k-core > 6, were regarded as topological central networks. Red-marked nodes represented up-regulated hub genes participating in three sub-networks, and the green marked ones represented down-regulated genes