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. 2019 Mar 29;17:4. doi: 10.1186/s12959-019-0194-8

Table 2.

PAR2 cleaving proteases

	Protease	Major cleavage site	Additional cleavage sites
Mammalian proteases	Thrombin	R³⁶S³⁷
	aPC	unknown
	FXa	R³⁶S³⁷
	Trypsin	R³⁶S³⁷	K³⁴G³⁵, K⁵¹G⁵², K⁷²L⁷³
	Tryptase	R³⁶S³⁷
	Chymase	G³⁵R³⁶	L³⁸I³⁹, mouse
	Matriptase	R³⁶S³⁷
	Cathepsin G	F⁶⁵S⁶⁶	F⁵⁹S⁶⁰, F⁶⁴S⁶⁵
	Cathepsin S	G⁴⁰K⁴¹	E⁵⁶P⁵⁷, mouse
	Neutrophil elastase	A⁶⁶S⁶⁷, S⁶⁷V⁶⁸	V⁴²D⁴³,V⁴⁸T⁴⁹,V⁵³T⁵⁴,V⁵⁸T⁵⁹,T⁷⁴T⁷⁵,V⁷⁶F⁷⁷
	Proteinase-3	D⁶²E⁶³	V⁴⁸T⁴⁹,V⁵⁵E⁵⁶,T⁵⁷V⁵⁸ V⁶¹D⁶²,K⁷²L⁷³,T⁷⁴T⁷⁵,T⁷⁵V⁷⁶,V⁷⁶F⁷⁷
	Plasmin	R³⁶S³⁷	K³⁴G³⁵
	Testisin	unknown
	Kallikrein-4,	unknown
	Kallikrein-5,-6,-14	R³⁶S³⁷
	Calpain-2	unknown
Non-mammalian proteases	Der-P1,-P2,-P3,-P9	unknown
	Cockroach E1-E3	R³⁶S³⁷
	Gingipain R	unknown
	LepA	unknown
	EPa	S³⁷L³⁸	S³⁸L³⁹, rat
	S.pneumoniae proteases	unknown
	Thermolysin	unknown
	Serralysin	unknown
	P.acnes proteases	unknown
	aPA	unknown
	Bromelain	unknown
	Ficin	unknown
	Papain	unknown
	penC	R³⁶S³⁷