Fig. 2.

Laser-based targeting of the FUS treatments: a Laser-based apparatus labeled “1”. b Underside view of the exit aperture of the laser labeled “2”. c Ablative exposures in beef muscle tissue were used to demonstrate the accuracy of the targeting, where three thermal lesions (arrows) are visible. The distance between the individual treatment locations was 6 mm. The thermal lesions (arrows) were created using continuous wave exposures at 20 W for a treatment duration of 30 s. Treatment planning and targeting with the laser is shown for a fourth location. d The targeting apparatus has been removed and the transducer brought into position for the treatment of the fourth lesion