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. 2019 Mar 29;19:281. doi: 10.1186/s12885-019-5486-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — CDDP treatment abrogates the growth of MOC-L1 xenografts. a Left, growth curve of subcutaneous MOC-L1 xenografts in C57BL/6 mice over seven weeks. Arrow, start point for intraperitoneally CDDP or normal saline injection. Lower, the resected tumors are harvested at endpoint. Right, quantification of tumor weight. CDDP treatment significantly decreases the weight of the MOC-L1 xenografts. b Upper, miRNA expression profile of the control tumors and the CDDP treated tumors. Lower, miR-196b expression. The results show a decrease in miR-196b expression in the CDDP treated tumors relative to the control tumors. c Correlation analysis. This reveals a correlation between miR-196b expression and the weight of the xenografts. **, p < 0.01; ***, p < 0.001