BM-SCs |
Scratch wound assay |
Wound closure |
3 days |
Human |
Stimulate fibroblasts, migration of keratinocyte and synthesis ECM proteins |
[238] |
BM-SCs |
Tail vein injection post-operatively |
Ischemia flap |
7 days |
Murine |
Enhance angiogenesis and vascular regeneration |
[141] |
autologous MSC |
Fibrin spray system |
Cutaneous wound |
12 weeks |
Murine and human |
Stimulate closure of full-thickness wounds in diabetic mice and wound healing repair |
[239] |
Combination hMSC with bFGF |
|
Cutaneous wound |
42 days |
Rat |
Increase re-epithelialization |
[240] |
Co-culture dermal fibroblasts with BM-SCs |
Scratch wound assay |
Wound closure |
3 days |
Murine |
Increase proliferation and migration of dermal fibroblasts |
[241] |
MSCs |
Subjection |
Incision wound |
4 days |
Mice |
Enhance tissue regeneration capacity especially in older populations |
[242] |
Autologous bone marrow |
Aspiration |
Chronic Wound |
5 weeks |
Human |
Rebuilding of dermal |
[138] |
MSCs |
Closed culture devices |
Radiation burns |
5 months |
Human |
Modulation radiation inflammatory process |
[243] |
Autologous MSCs |
Injection |
Diabetic ulcer |
4 weeks |
Human |
Successful healing |
[244] |
Allogeneic BM-SCs |
Intradermal |
Excisional wound |
14 days |
Murine |
Accelerate wound closure, increase re-epithelialization and angiogenesis |
[245] |
BM-SCs |
Aspiration |
Non-healing wound |
5 days |
Human |
Increase synthesis of collagen |
[246] |
MSCs |
Injection |
Cutaneous wound |
2 weeks |
Human |
Promote angiogenesis |
[247] |
MSCs |
Mechanical loading |
Incision wound |
|
Mouse |
Enhancement of angiogenesis |
[248] |
hUC-MSCs) |
Transplantation |
Burn |
8 weeks |
Rat |
Decrease inflammatory cells, increase neovascularization and enhance collagen level |
[249] |
ASCs |
Transplantation |
Non-irradiated and irradiated |
14 days |
Mouse |
Promote dermal wound healing, enhance wound closure and collagen secretion |
[250] |
hESCs |
Grafting |
Burn |
Enhanced wound healing |
Human-mice |
hESC-derived epidermis showed a pluristratified structure, consistent with that of mature native human skin |
[251] |
ESCs |
Directly on a gauze |
Chronic Wounds |
Accelerated wound healing |
Diabetic mice |
The beneficial effects were evident both histopathologically and immunohistochemically |
[252] |
Mouse-iPSCs |
Grafting |
Inherited skin disorders |
Enhanced wound healing |
Mouse |
iPSC-KC stem cells were able to regenerate the epidermis, hair follicles, and sebaceous glands in an in vivo graft assay |
[253] |
hiPSC-MSCs-Exos |
Injected locally |
Injured tissues |
Facilitated cutaneous wound healing |
Human-rat |
Accelerated re-epithelialization, reduced scar widths, the promotion of collagen maturity, promoted the generation of newly formed vessels, accelerated their maturation in wound sites |
[254] |
hiPSC |
Grafting |
Skin disease |
Reconstitution of normal skin structures |
Human-SCID mice |
Skin appendages, such as hair follicles and glands, were not detected, and no cyst or tumor formation |
[255] |
hiPSCs |
Grafting |
Inherited skin disorder |
Reconstitute human skin |
EB patient-SCID mice |
The reconstituted skin expressed human Col17 at the basement membrane zone, human type VII collagen and human keratin 14 were expressed in the basal layer |
[256] |