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. Author manuscript; available in PMC: 2019 Mar 29.
Published in final edited form as: Am J Transplant. 2018 Dec 25;19(3):884–893. doi: 10.1111/ajt.15196

FIGURE 1.

FIGURE 1

IRF4 deletion in T cells induces transplant tolerance in heart graft recipients. Irf4fl/flCd4‐Cre mice were transplanted with BALB/c hearts. Thirty days later, recipients were transplanted again with BALB/c and C3H skins (n = 5). A, Schematic of the experimental design. B, The percentage of skin allograft survival after skin transplantation on BALB/c heart‐transplanted Irf4fl/flCd4‐Cre recipients. **P = .0079; Mann‐Whitney test. C, Representative images of accepted BALB/c skin allografts (>100 days) on BALB/c heart‐transplanted Irf4fl/flCd4‐Cre recipients. D, A representative image of C3H (left) and BALB/c (right) skin allografts on a BALB/c heart‐transplanted Irf4fl/flCd4‐Cre recipient