Table 4: The mean and standard deviations of free energy corrections based on ligand external entropy:

restricting the ligand to the binding site (∆G_ξ) and of imposing a confining potential on translational and rotational degrees of freedom (∆G_c). The latter is based on ∆G_c = ∆G_c,L − ∆G_c,RL and does not include importance sampling effects through $\Delta G_{RL}^c$.

Set	∆Gξ	∆Gc
Bromodomains	1.98 (0.41)	5.74 (1.05)
FXR	2.20 (0.32)	7.42 (0.92)
hPNMT	2.06 (0.28)	7.43 (1.18)
Lysozyme	1.46 (0.14)	4.94 (0.48)
MAP4K4	1.98 (0.35)	7.33 (0.77)
IE	6.96 (1.38)	11.62 (1.28)